Synthesis of 1-(2-Naphthylsulfonyl)pyrazole-C-Glycosides

Abstract

2-Naphthylsulfonylhydrazine was reacted with aromatic aldehydes or aldehydo sugars to give the corresponding hydrazones which undergo Michael addition reactions with malononitrile or ethyl cyanoacetate to form pyrazole derivatives.

Synthesis of some 4-(2′-hydroxyaryl)-5-ethyl-2-(N, N-dialkylamino)-1,3-dithiolium salts

“…Kinetic [16][17][18] and structural [19][20][21][22][23][24] studies reveal that NNIs inhibit the enzyme noncompetitively, binding to an allosteric site some 10 Å from the polymerase catalytic site. As part of our continuing program of research on the synthesis of new nucleosides and non-nucleosides [25][26][27][28][29][30], we report…”

“…) d (ppm): 7.95 (d, J ¼ 8 27. Hz, 1H, H-5),7.44 (s, 1H, H-2), 6.93-6.39 (m, 8H, ArÀ ÀH), 5.11 (s, 2H, H-1 0 ), 3.87 (s, 2H, OÀ ÀCH 2 C 6 H 5 );13 C NMR (DMSO-d6 ) d (ppm): 187.71 (C¼ ¼S), 144.09 (C-2), 142.27, 136.24, 134.72, 130.62, 128.44, 126.80 (C-arom.…”