Synthesis of 1,2,4‐triazolo[1,5‐a]pyrimidine‐2‐sulfonamides

Abstract

The 1,2,4‐triazolo[1,5‐a]pyrimidine‐2‐sulfonamides are a new class of highly active herbicides. A novel cyclization method for the synthesis of these compounds is discussed.

An Expeditious Synthesis of 1,2,4-Triazolo[1,5-<i>a</i>]Pyrimidine

“…Some examples of published derivatives of 1,2,4-triazolo [1,5- Thus in view of finding novel analogues of triazole [1,5-a]pyrimidine with potential biological activities, we set upon a synthetic program involving 5-amino,1,2,4-triazole as building block. Although different strategies have been employed for the synthesis of these compounds, [11][12][13][14][15] these methods suffer from drawbacks such as long reaction times, cumbersome isolation of the products and harsh reaction conditions. Herein, we report a facile and efficient multi-component synthesis of 1,2,4-triazolo [1,5-a]pyrimidine in excellent yields from 3-amino-1,2,4-triazole, aldehydes and ethyl 3-oxo hexanoate respectively by simple fusion followed by adding catalytic amount of dimethylformamide (Scheme 1).…”

Synthesis and Characterization of Imidazo[1,2-a]Pyrimidine

“…Some examples of reported biologically active compounds of Imidazo [1,2-a] Thus in view of above facts our plan was to synthesised novel analogues of imidazo[1,2-a]pyrimidine with potential biological activities, we set upon a synthetic strategies involving 2-amino-benzimidazol as building block. Although different strategies have been employed for the synthesis of these compounds, [13][14][15][16][17] these methods suffer from drawbacks such as long reaction times, cumbersome isolation of the products and harsh reaction conditions. Herein, we report an efficient one-pot multi-component synthesis of imidazo[1,2-a]pyrimidine afforded excellent yields from 2-amino-benzimidazole, aldehydes and ethyl 3-oxo hexanoate respectively by simple fusion followed by adding catalytic amount of dimethylformamide (Scheme 1).…”

A convenient route to synthesize 1,2,4‐triazolo[1,5‐a]pyrimidine derivatives and their one and two‐photon absorption spectral properties

“…On the other hand, the chemistry of 1,2,4-triazolo[1,5-a]-pyrimidine derivatives have been of considerable interest for many years, its various derivatives have found applications in pharmaceutical, agricultural and other areas [13][14][15]. Recently, we become interested in the synthesis of new 1,2,4-triazolo [1,5-a]pyrimidines, and their use as TPA materials, especially, it is of utmost importance to synthesize some pyrimidine derivatives by a simple and effective method.…”