“…[34] The 1,2,3-triazole conjugate of hydnocarpic acid, (R)-[1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl]methyl-11-(cyclopent-2-en-1-yl)undecanoate (13) showed promising antiproliferative activity F I G U R E 1 Biologically active 1,2,3-triazole drugs F I G U R E 2 Mechanisms of action of 1,2,3-triazole hybrids with an IC 50 value of 63.96 μM, which was 2.5-fold more effective than hydnocarpic acid (157 μM) against A549 cells. [35] As a novel 1,2,3-triazole derivative of ametantrone, 14 showed cytotoxic effects with IC 50 values of 13.5, 4.5, 13.1, and 9.8 μM on A431, BxPC3, HCT-15, and CCD-34Lu, respectively [36] (Figure 3).…”