Synthesis, nucleic acid binding and cytotoxicity of oligonuclear ruthenium complexes containing labile ligands

Cooperative effects in homogenous water oxidation catalysis by mononuclear ruthenium complexes

“…For example, mediator-catalyst assemblies can be attached to, for example, dyed-titania semiconductor films to construct photoanodes capable of splitting water with visible light. 15 13 have been reported previously and the same methods were used in the present work. In a typical synthesis, solid [Ru(terpy)Cl 3 ] (0.20 g, 0.45 mmol) and appropriate amounts of the ligands (0.084 g, 0.45 mmol for Me 2 bpy and 0.071 g, 045 mmol for bipy) were refluxed in EtOH-H 2 O (4 : 1; 40 ml) for 4 h. After cooling, the solvent mixture was evaporated to dryness.…”

“…2+ 11,13. Integration of the two proton resonances reveals that the mixture contains approximately 90% [Ru(terpy)(Me 2 bipy)Cl] + and 10% [Ru(terpy)(Me 2 bipy)(OD 2 )]2+ .…”

DNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium(ii) terpyridine complexes

“…It was found that most of the Ru(II)-tpy complexes are capable of binding covalently to DNA (mainly at guanine residues) forming monofunctional adducts and DNA replication was stopped by some of them. 25,29 Recently, we developed a series of new ruthenium polypyridyl complexes of the general formula mer-[Ru(L 3 )(N-N)X][Y] n in which L 3 is either tpy or Cl-tpy (4′-chloro-2,2′:6′,2″-terpyridine), X = Cl or DMSO-S, N-N = en, dach or bpy, Y = Cl, PF 6 or CF 3 SO 3 , and n = 1 or 2, depending on the nature of X. 30 Since all these compounds were cationic, with the aim of evaluating the behavior of a neutral complex, the synthesis and characterization of a Ru(II)-tpy complex with the anionic N-O chelating ligand picolinate (4) (Fig.…”

Multinuclear ruthenium(ii) complexes as anticancer agents

“…2; where bb n = bis[4(4 0 -methyl-2,2 0 -bipyridyl)]-1, n-alkane, for n = 7, 10, 12, and 14}. 30 The Cl-Rubb n complexes showed good activity against the highly sensitive L1210 cell line (IC 50 E 5-10 mM) and were ten-times more active than the corresponding mononuclear complex [Ru(tpy)(Me 2 bpy)Cl] + {Me 2 bpy = 4,4 0 -dimethyl-2,2 0 -bipyridine}. 30 In this present study we sought to extend the family of Cl-Rubb n dinuclear complexes by using a similar approach to that of Farrell and co-workers for the multinuclear platinum complexes.…”

“…30 The Cl-Rubb n complexes showed good activity against the highly sensitive L1210 cell line (IC 50 E 5-10 mM) and were ten-times more active than the corresponding mononuclear complex [Ru(tpy)(Me 2 bpy)Cl] + {Me 2 bpy = 4,4 0 -dimethyl-2,2 0 -bipyridine}. 30 In this present study we sought to extend the family of Cl-Rubb n dinuclear complexes by using a similar approach to that of Farrell and co-workers for the multinuclear platinum complexes. 2,[9][10][11] Consequently, we have synthesised and examined the anticancer activities, rates of hydrolysis, and binding ability to guanosine 5 0 -monophosphate (GMP) of a series of Cl-Rubb n complexes that contain cationic groups (NH 2 + ) in the chain of the bb n linking ligand (Cl-RubbN n ).…”