2023
DOI: 10.1007/s11224-023-02210-3
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Synthesis, NoSpherA2 refinement, and noncovalent bonding of abiraterone bromide monohydrate

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Cited by 5 publications
(5 citation statements)
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“…Unfortunately, the only iron(II) complex with AbirAc was obtained by reaction of FeBr3 with AbirAc in acidic media and had the composition (Abi-rAcH)[FeBr4] (11). With the absence of HBr, single crystals of (HAbirOH)Br • H2O and colloid Fe(OH)3 precipitated from the same FeBr3:AbirAc = 1:1 mixture, and the structure of this salt has been published elsewhere [37]. The recrystallization of AbirAc from 2M and concentrated 48% HBr affords only the starting AbirAc.…”
Section: Molecular and Crystal Structuresmentioning
confidence: 99%
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“…Unfortunately, the only iron(II) complex with AbirAc was obtained by reaction of FeBr3 with AbirAc in acidic media and had the composition (Abi-rAcH)[FeBr4] (11). With the absence of HBr, single crystals of (HAbirOH)Br • H2O and colloid Fe(OH)3 precipitated from the same FeBr3:AbirAc = 1:1 mixture, and the structure of this salt has been published elsewhere [37]. The recrystallization of AbirAc from 2M and concentrated 48% HBr affords only the starting AbirAc.…”
Section: Molecular and Crystal Structuresmentioning
confidence: 99%
“…Thus, attempts to find more soluble and less food-dependent forms of abiraterone are still ongoing. The search for novel solid forms of AbirAc with enhanced solubility included co-crystallization of AbirAc with some co-formers [ 34 , 35 ] and formation of (HAbirOH)Hal · H 2 O salts (Hal = Cl – [ 36 ]; Br – [ 37 ]). Based on numerous X-ray diffraction data of ligand (AbirOH): receptor (human cytochrome P450 17A1 or CYP17A1) complexes, the most specific feature of their binding is coordination between the iron atom of the heme fragment and the nitrogen atom N Py of the pyridine-3-yl ring of abiraterone [ 38 , 39 , 40 , 41 , 42 ].…”
Section: Introductionmentioning
confidence: 99%
“…Within our study of the crystal and molecular structures of the solid forms of active pharmaceutical ingredients [7][8][9], the powder pattern of alectinib hydrochloride was measured using CuK α radiation. Room temperature was maintained to overcome the effects of thermal contraction and to avoid possible phase transitions.…”
Section: Introductionmentioning
confidence: 99%
“…This information is required for phase identification and purity control. In our study of novel solid forms of known active pharmaceutical ingredients [7][8][9], the ability of sumatriptan succinate to form various solvates was examined. Recrystallization from ethanol afforded a hemisolvate, HSum + •HSucc − •0.5EtOH (1).…”
Section: Introductionmentioning
confidence: 99%