Synthesis, NMR, FT-IR, X-ray structural characterization, DFT analysis and isomerism aspects of 5-(2,6-dichlorobenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Crystal structure of diethylammonium 1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-ide, C10H19N3O3

“…In the meanwhile, barbituric acid has been found to be associated with important biological activities including anti-hypertensive, anti-in ammatory, antitumor, anticonvulsant and hypnotic drugs [1][2][3][4][5][6][7][8][9][10][11][12]. We have succeeded to separate the active species which can act as nucleophile generated by aqueous diethylamine medium.…”

Crystal structure of 5-(3-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione; C13H11FN2O3

“…Additionally, barbituric acid derivatives exhibit antifungal, antimicrobial, antiviral, potential mushroom tyrosinase inhibition, antituberculosos, radio-sensitization, anticancer with anti-in ammatory activities, inhibition for diaminopimelate aminotransferase, and anti-proliferative activity [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Crystal structure of 5-((4-bromophenyl)(2-hydroxy-6-oxocyclohex-1-en-1-yl)methyl)-6-hydroxy-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, C19H19BrN2O5

“…For example bucolome, veronal, phenobarbital, seconal, and sodium pentothal representatives have clinical use as anti-in ammatory and hypnotic drugs which are derived from barbituric acid sca old [2][3][4]. On the other hand, this sca old possessing antitumor, antihypertensive, sedative, anticonvulsant, anti-oxidant, and anti-diabetic potentials [5][6][7][8][9][10][11]. We have described in this text the synthesis of a new pyrimidines derivatives via one pot Aldol-Michael reactions in aqueous diethylamine medium.…”