Synthesis, Morphology, and Optical Properties of Au/CdS Hybrid Nanocomposites Stabilized by Branched Polymer Matrices

Background: Given the urgency of the problem of clinical and experimental pathology of diabetes mellitus (DM) and the reproductive function disorders and their correction, the direction of research was determined in the following way: to establish the functional state of testicular cells and appendages under experimental hyperglycemia, and to assess future prospects for gold nanoparticles for clinical trials. The aims to evaluate the effect of five times treatment with gold nanocomposites (gold nanoparticles (AuNPs) in the polymer matrix D-g-PAA(PE) on male reproductive function under conditions of experimental hyperglycemia.Methods: Experiments (two series) have been conducted on 120 (60 males and 60 females) Albino white laboratory mice (weighing 25-30 gm). Experimental hyperglycemia, a model of type 2 diabetes mellitus (DM2) was reproduced by administration of nicotinamide and streptozotocin (internally peritoneally). The treatment of substances was carried out in the following way: D-g-PAA (PE) (10.00 mg/kg), D-g-PAA (PE)/AuNPs (9.78 mg/kg) in the tail vein, in 0.3 ml, once a day, five times, 2 weeks after EG induction once a day, five times.Results: it was established for the first time that there is disorder of male reproductive function under conditions of experimental hyperglycemia and five-fold treatment of gold nanocomposites (D-g-PAA(PE)/AuNPs, namely an increase in the number of abnormal sperm and a decrease in spermatids, as well as an increase in preimplantation mortality of embryos (compared to this value under experimental hyperglycemia).Conclusions: Our new data suggest that treatment with such gold nanocomposites (gold nanoparticles in D-g-PAA (PE) polymer matrix) are not critical for therapeutic use (in photodynamic chemotherapy), even in hyperglycemia when there is diabetes.

show abstract

“…Details of synthesis, identification and analysis of gold nanoparticles have been described in literature. [12][13][14][15][16][17]…”

Section: Synthesis and Characterization Of Polymer/aunps Nanosystemmentioning

confidence: 99%

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Kaleynikova

Ukrainska

Sribna

et al. 2022

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Під керівництвом д-ра хім. наук Н. В. Куцевол [72][73][74][75][76][77][78] вивчаються розгалужені водорозчинні полімери, які відповідають теоретичним моделям сферичних і циліндричних полімерних щіток. Було синтезовано й досліджено кополімери декстран-поліакриламід та декстран сульфат-поліакриламід та їхні аніонні похідні.…”

Section: д г вишневський)unclassified

“…Синтезовані розгалужені полімери є високоефективними матрицями для синтезу стабільних золів золота, срібла CdS та наногібридів Au / CdS (рис. 5) [76][77][78].…”

Section: д г вишневський)unclassified

See 1 more Smart Citation

From Organics to Polymers

Kolendo

Savchenko

Vretik

et al. 2017

Bull. T. Shevchenko Nat. Univ. Kyiv. Chem.

View full text Add to dashboard Cite

Polymers, composites, their components and complexes for application in information tecnologies and biotechnology as well as for medicine and solar energy transfer have been obtained. In particular, new high-resolution photochromic polymer materials with a significant nonlinear optical effect of the third order have been developed. They are perspective for the creation of high-speed optical switches in optical recording and information storage. A new way of recording information based on the generation of the second harmonic with new photochromic polymers has been found. The perspectivity of alken-functionalised poly(phenyl/naphthylmethacrylates) as basic compounds for polarization-sensitive polymeric media was prooved.The chemical modification of polymers by benzenesulfonamide derivatives for biostabilization of plastic masses and providing hydrophilic properties for their surface was carried out. A fundamentally new approach is developed in which processes of energy transfer of excited states in polymer macromolecule to the photostabilaser are used for effective stabilization of polymer materials. Thermostabilized samples of polystyrene with covalently bonded of imidophenylmethacrylates have been developed. The branched copolymers are highly efficient matrices for the synthesis of stable gold, silver, CdS and Au / CdS nanoparticles and copolymers that can be used as nanovectors for the target delivery of highly toxic antitumor drugs. New effective preparations for desinfaсtion of fish nurseries, dressing and hygienic materials, linen and clothes have been developed.

show abstract

Synthesis of Au nanoparticles–decorated CdS nanowires via laser ablation in liquid for optoelectronic applications

2018

View full text Add to dashboard Cite

Synthesis, Morphology, and Optical Properties of Au/CdS Hybrid Nanocomposites Stabilized by Branched Polymer Matrices

Cited by 8 publications

References 47 publications

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

Effect of gold nanocomposites treatment on male reproductive function under conditions of experimental hyperglycemia

From Organics to Polymers

Synthesis of Au nanoparticles–decorated CdS nanowires via laser ablation in liquid for optoelectronic applications

Contact Info

Product

Resources

About