Synthesis, molecular structure investigations and antimicrobial activity of 2-thioxothiazolidin-4-one derivatives

Crystal structure of (Z)-5-(4-chlorobenzylidene)-2-thioxothiazolidin-4-one —dimethylsulfoxide (1:1), C12H12ClNO2S3

“…On the other hand, this sca old shows antifungal, antibacterial, antiviral, anti-in ammatory, anticonvulsant, anti-diabetic, anti-proliferative, anti-tubercular, anti-hyperlipidemic, and cardiovascular activities. In continues of our research [2,3] we report the crystal structure of a new thioxothiazolidin-4-one compound [4][5][6]. The title compound, C 12 H 12 ClNO 2 S 3 comprise of a planar thioxothiazolidin-4-one heterocycle (S2-C1/N1/C2/C3).…”

Crystal structure of 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid monohydrate, C5H7NO4S2

“…The rhodanine derivatives of 3-alkilocarboxylic acids have been exhibited pharmaceutical targets. Their antiin ammatory, antifungal, antituberculous, antibacterial, antiviral, and anticancer potentials have been reported [1][2][3][4][5][6][7][8][9][10]. The title compound was synthesized via reaction of corresponding amino acid, chloroacetic acid and carbon disulphide [11].…”

Synthesis, Molecular Structure and Spectroscopic Investigations of Novel Fluorinated Spiro Heterocycles

“…The Michael addition reaction is one of the most remarkable tools for C-C bond construction in organic synthesis [25,26,27,28,29,30,31,32]; in particular intermolecular double-Michael reactions are the most powerful tool for assembling spirocyclic products from the non-cyclic starting materials.…”

“…As a part of our ongoing program to develop efficient and robust methods for the preparation of biologically relevant compounds from readily available building blocks [25,26,27,28,29,30,31,32], we have extended our work to synthesize some new fluorine compounds derived from barbituric acid spiro-heterocycles. Herein, we report the regioselective synthesis in excellent yield of 7,11- bis (4-fluorophenyl)-2,4-dimethyl-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraone ( 3a ) 2,4-dimethyl-7,11- bis (4-(trifluoromethyl)-phenyl)-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraone ( 3b ).…”