Synthesis, Molecular Structure and Reactivity of 5-Methylidene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolines

Structural and vibrational study of 2‐(2′‐ furyl)‐4,5‐1H‐dihydroimidazole

“…The two antisymmetric stretching modes of these groups can be assigned to IR bands at 2951 and 2931 cm −1 , while their corresponding symmetric modes are assigned to the IR bands at 2891 and 2865 cm −1 . The band of medium intensity and the weak band in the IR spectrum at 1474 and 1454 cm −1 , respectively, are assigned to the scissoring modes in agreement with those of heterocyclic compounds containing the imidazoline ring;67 in contrast, as the calculation predicted, the bands of the medium and strong intensities at 1309 and 1275 cm −1 are assigned to wagging modes. Among the two expected twisting modes, only one is assigned to the medium intensity band localized at 1122 cm −1 , while the remaining rocking mode, calculated at 1193 cm −1 , was not assigned.…”

“…4. The assignment of the experimental bands to the normal modes of vibration for the anti conformer of 1 were made on the basis of the potential energy distribution (PED) in terms of symmetry coordinates, using the B3LYP/6‐311++G** data and taking into account the corresponding assignment of related molecules 61–76. The assignment of the vibrational normal modes and the PED based on the 6‐311++G** basis set are shown in Table 7, while those obtained with the 6‐31G* basis set are shown in Table S2.…”

Microwave assisted synthesis of triazoloquinazolinones and benzimidazoquinazolinones

“…Moreover, the imidazoquinazolinones have the activity to afford agents capable of lowering the blood pressure of experimental animals. [18] Additionally, naturally occurring substances as known such as clonidine and moxonidine or belong to this class exhibit antihypertensive activity mediated by α-adrenergic and/or imidazoline receptors. [19] Recently, it was reported on an efficient strategy for the preparation of structural variant of imidazoquinazolinones with three-point diversity.…”

Cycloaddition Reactions of Enamines

“…[44] Imidazo[2,1-b]quinazoline 131 with the enamine moiety interacts with the appropriate nitrones 132, forming 1,2,3,5tetrahydro-imidazo[2,1-b]quinazolin-5,5'-spiro-2',3'-diphenylisoxazolidines 133 (Scheme 42). [45] Initial enamine 131 was obtained by the reaction of 2-chloro-4,5-dihydroimidazole with 2-amino-acetophenone.…”