Synthesis, Molecular Docking Study, and Anticancer Activity of 7-Azaindole-1,2,3-triazol Bearing N-Benzamide Derivatives

Efficient and fast screening and separation based on computer‐aided screening and complex chromatography methods for lipoxygenase inhibitors from Ganoderma lucidum

“…a holistic perspective and further verify the results of UF. [15][16][17][18] Finally, enzyme kinetics was used to analyse the rate and determine the factors of the enzyme-catalysed reactions. These tests examined the enzymecatalysed reaction rate, structure-activity relationship, and various factors affecting the reaction rate.…”

“…The ligand–receptor complex can be isolated from unbound compounds to improve drug discovery throughput, 13 thereby rapidly screening LOX inhibitors in G. lucidum . Subsequently, computer‐assisted screening (molecular docking and network pharmacology) was used to simulate the molecular geometry and intermolecular forces using stoichiometric methods, 14 and systems biology, multidirectional pharmacology, computational biology, network analysis, and other disciplines were integrated to explore the relationship between G. lucidum and AD from a holistic perspective and further verify the results of UF 15–18 . Finally, enzyme kinetics was used to analyse the rate and determine the factors of the enzyme‐catalysed reactions.…”

Design and synthesis of Meldrum's acid based 7-azaindole anchored 1,2,3-triazole hybrids as anticancer agents

“…These new hybrids are always endowed with increased activity or novel biological features, in comparison to their respective components. 30 Hybridization of 7-azaindole with 1,2,3-triazoles eventually presented a wide spectrum of biological activity such as antimicrobial, 31 anticancer, 32 DNA binding, 33 etc. On the other hand, cancer has been a very serious health issue that kills people of all ages all over the world.…”