Synthesis, molecular docking, antimicrobial, antioxidant and anticonvulsant assessment of novel S and C-linker thiazole derivatives

Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors

“…Aiming to combine two bioactive entities, quinazoline and thiazole, into a single compact hybrid structure to create EGFR kinase inhibitors, the current work was motivated by all of these facts and continued our earlier efforts to plot and synthesize new therapeutic agents [ [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] ]. As EGFR-mutant kinase inhibitors for the treatment of NSCLC human breast (MCF-7), liver (HepG2), and lung (A549) cancer cell lines, we developed and synthesized new quinazoline-based thiazole compounds.…”

New Thiazole Acetic Acid Derivatives: A Study to Screen Cardiovascular Activity Using Isolated Rat Hearts and Blood Vessels

“…The agents were found to be effective even in cancer and HIV in addition to the already reported activities [ 10 , 11 , 12 ]. The search for newer activities for this class of compounds is intensifying as a growing number of activities are reported [ 13 , 14 ]. Additionally, substitutions such as O-, N- and S- were found to play an important role in the modification of both the pharmacokinetic and pharmacodynamic properties of the heterocyclic compounds [ 15 ].…”