Synthesis, Molecular Docking and Pharmacological Study of Some New Thiopyrimidine Derivatives

Lal, Kundan; Paliwal, L. J.; Bagade, Mahendra B.

doi:10.1016/j.matpr.2018.05.017

Cited by 2 publications

(2 citation statements)

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“…The 2-thiopyrimidines was found to have excellent antimicrobial [17] [18] [19], antiviral [20], anti-inflammatory [21] and antitumor [22] properties. Therefore, 2-thiopyrimidines gained more attention from worldwide organic chemists [23]. Furthermore, the benzimidazole ring also had a panel of biological activities [24] [25] [26].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Antibacterial Activities of New 2-(Benzylthio)pyrimidines and 2-(Benzimidazolylmethylthio)pyrimidines Derivatives

Achi¹,

Coulibali²,

Zon³

et al. 2021

OJMC

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A series of 2-(benzylthio)pyrimidines (6a-l) and 2-(benzimidazolylmethylthio)pyrimidines derivatives (6m and 6n) analogues of ethyl 2-(benzylthio)-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylates and ethyl 2-(((1H-benzimidazol-2-yl)methyl)thio)-6-methyl-4-phenyl-1,4-dihydropyri-midine-5-carboxylates were prepared and evaluated for antibacterial activity. These compounds were obtained by condensation of 2-thiopyrimidines (4) with benzyl halides or 2-(chloromethyl)-1H-benzimidazole (5) in the presence of a base. All compounds were characterized by 1 H, 13 C and HRMS spectra. Out of fourteen, only eight compounds were screened against multi-resistant strains of Escherichia coli and Staphylococcus aureus. The results revealed that all of them were found to possess significant antibacterial activity against the germs tested. Compounds 6c, 6d, 6h and 6m were more active on S. aureus and compounds 6h and 6m more active on E. coli.

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Section: Introductionmentioning

confidence: 99%

“…Hz, 3H, CH 3 );13 C NMR (75 MHz, CDCl 3 ) δ (ppm) 166 23,. 163.82, 160.47, 142.69, 139.13, 138.51, 136.31, 129.93, 129.82, 129.70, 128.93, 127.14, 106.46, 61.13, 54.65, 52.19, 36.40, 21.09, 17.31, 14.02; HRMS (ESI): Calc for C 24 H 27 N 2 O 4 S (M+H) + : 439.1232.…”

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confidence: 99%