“…[13,14] The classification of ureases has been done in two different groups (i) active-site-directed inhibitors (substrate-like) such as hydroxamic and hydroxyurea (ii) mechanism-based-directed inhibitors, for instance, imidazoles and phosphorodiamidates. [15] Recently, several classes of compounds including hydroxamic acids, [16,17] phosphoramidites, [18] boronic and boric acids, [19] quinones, [20,21] heavy metal ions, [22] imidazoles, [23] and others have been investigated as urease inhibitors. [24][25][26][27][28][29][30] The bacterial ureases can also be inhibited by the five-membered heterocycles like 1,2,4 triazoles and 1,3,4 oxadiazoles.…”