Synthesis, Molecular Docking and Biological Evaluation of Some Novel N-Carbamoyl Pyrazolines as Potent Anti-Inflammatory, Antioxidant and Antidiabetic Agents

Peerzade, Nargisbano A.; Jadhav, Shravan Y.; Bhosale, Raghunath B.

doi:10.31788/rjc.2020.1335637

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The synthesized pyrazole aldehyde was then reacted with various methoxy substituted acetophenone pyrazolechalcone ( 36 a – j ). To synthesize the n‐carbamoyl pyrazoline derivative ( 37 a – j ), semicarbazide was added to the pyrazolechalcone [63] . (Scheme 12)…”

Section: Chemistry Of Chalcone Derived Pyrazoline Derivativesmentioning

confidence: 99%

“…Compounds ( 37 j ) (R=H, R′=H) and ( 37 b ) (R=−OMe, R′=4−OMe) were found more potent antidiabetic than other compounds. The compounds ( 37 a ) (R=H, R′=4−OMe), (R=H, R′=2,4−di−OMe) ( 37 d ), (R=−OMe, R′=3,4,5−tri−OMe) ( 37 g ) and (R=H, R′=H) ( 37 j ) betrayed phenomenal antioxidant activity for DPPH radical while the compound (R=−OMe, R′=3−OMe) ( 37 f ) displayed maximum inhibition for NO and SOR free radical [63] …”

Section: Chemistry Of Chalcone Derived Pyrazoline Derivativesmentioning

confidence: 99%

See 1 more Smart Citation

An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

2021

View full text Add to dashboard Cite

Chalcones are α, β unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti‐inflammatory, antimicrobial, and antimalarial. Nitrogen‐containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N‐ heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone‐based pyrazolines and their derivatives with the available data till 2021.

show abstract

Section: Chemistry Of Chalcone Derived Pyrazoline Derivativesmentioning

confidence: 99%

Section: Chemistry Of Chalcone Derived Pyrazoline Derivativesmentioning

confidence: 99%