Synthesis, molecular docking and biological evaluation of 2,4 disubstituted quinazolines with multi-target activities as anti-cancer and antimicrobial agents

Synthesis and antimicrobial study of new tetrazole, benzimidazole and N3-functionalized quinazolinone derivatives

“…iQuinazolinone skeleton iis ifrequently iencountered ias ia ibuilding iblock ifor ihundreds iof inaturally ioccurring ialkaloids i [1,2]. i iSynthesis iof iquinazolinone iheterocycles ihas ibroad iimportance iin iorganic isynthesis iaccording ito itheir iextensive iimportance iin imedicinal ichemistry ibecause iof itheir idiverse ipharmacological iactivities iincluding iantibacterial i [3,4,46], iantimalarial i [5], iantifungal i [6][7][8]47], i iantihypertensive i [9,10], iantihistaminic i [11], ia ilocal ianesthetic i[12], ianti-iParkinson i [13], icardiotonic i [14], ianticancer i [15][16][17][18][19][20][21], iantiviral i [22,23] iand ithymidylate isynthase iinhibitory iactivities i [24]. iSeveral isimple iand icondensed iquinazolines iare ialso iknown ito iexhibit ipotent iCNS iactivities ias ian ianalgesic i [25], ianti-inflammatory i [26][27][28] iand ianticonvulsant iactivities i [29,30].…”