Synthesis, molecular docking and anticancer activity of 5,5'-(phenylmethylene)bis(6-amino-2-thiouracil) derivatives

Aremu, Oluwole Samuel; Alapour, Saba; Manhas, Neha; Singh, Moganavelli; Singh, Pushpinder; Koorbanally, Neil A.

doi:10.1080/10426507.2021.1946060

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Aremu et al [50] . synthesised a series of 5,5’‐(phenylmethylene) bis (6‐amino‐2‐thiouracil) derivatives of the type 56 a – f .…”

Section: Introductionmentioning

confidence: 99%

“…Armand et al [49] synthesised Aremu et al [50] synthesised a series of 5,5'-(phenylmethylene)bis( 6 Sanduja et al [52] synthesised uracil-coumarin based hybrid molecules 65 a-g by click chemistry. The reaction involved the treatment of 4-hydroxy coumarin 60 with dibromoalkanes to yield the product 61 which further reacted with sodium azide (NaN 3 ) in DMF to form azide substituted coumarins 62.…”

Section: Introductionmentioning

confidence: 99%

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Uracil: A Pharmacophore with Diverse Biological Potential

Jain,

Sharma,

Utreja

2024

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This review article delves into the intricate biological activities of uracil, an essential pyrimidine Base pivotal in RNA structures. Examining its involvement in nucleic acid metabolism, various multifunctional roles, spanning from influencing cell proliferation to its antimicrobial and antiviral properties. The study explores signal transduction pathways affected by uracil, unraveling potential therapeutic applications. By unraveling the nuanced biological mechanisms. This review contributes to a deeper understanding of uracil's impact, offering insights crucial for drug development and advancing biomedical research.

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“…Aremu et al [50] . synthesised a series of 5,5’‐(phenylmethylene) bis (6‐amino‐2‐thiouracil) derivatives of the type 56 a – f .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uracil: A Pharmacophore with Diverse Biological Potential

Jain,

Sharma,

Utreja

2024

ChemistrySelect

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“…Some studies indicated that 2-thiouracil has an inhibitory effect on the growth of some culture viruses [4,5], but this inhibitory effect is very limited against animal viruses such as inhibiting the growth of vaccinia virus in tissue culture [6] as well as its ability to disable poliovirus [7]. In this context, we have focused in this research on thiouracil compounds due to diversity of their biological activity as antibacterial [8][9][10][11], antifungal [12][13][14], anticancer [15][16][17][18], antioxidant [19,20], antiviral [21][22][23], antithyroid [24,25]…etc. agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of The Antiviral Activity of Novel 2-Thiopyrimidine-5-Carbonitrile Derivatives

et al. 2022

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2-Thiouracil-5-carbonitriles are promising compounds that have been prepared in the last twenty years and have proven to have a diversity of biological activity. In line with this approach, our new compounds were prepared starting from Biginilli condensation of thiourea, ethyl cyanoacetate and 2,4-dichlorobenzaldehyde in basic medium to give a thiouracil derivative (1) which was subjected to chlorination at4 th position by POCl3/PCl5 mixture producing chloropyrimidine (2) which in turns was reacted with m-aminoacetophenone in pyridine yielding acetyl derivative (3) which was condensed with a series of four aromatic aldehydes in alcoholic sodium hydroxide producing chalcones (4a-d) which were used as starting materials for the preparation of many heterocyclic nuclei by their reaction with hydrazine, phenyl hydrazine, hydroxylamine HCl, thiourea, ethyl cyanoacetate /ammonium acetate, malononitrile, ethyl cyanoacetate/acetic acid/sodium acetate to give pyrazoline, phenyl pyrazoline, isoxazoline, thiopyrimidine, pyridinone, aminopyridine and aminopyran derivatives (5a-d) to (11a-d) respectively . Some of the newly synthesized compounds were investigated as antiviral agents. Compounds (2), (7a), and (7c) show promising antiviral activity against Bovine Viral Diarrhea Virus (BVDV). The structures of the newly synthesized compounds were confirmed by elemental analysis in addition to spectral data and physical methods.

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