Synthesis, modeling and biological activity of new zinc(II) hydroxamates against streptococcus pneumoniae

Gonçalves, Bruna Lisboa; Ramos, Daniela Fernandes; Halicki, Priscila Cristina Bartolomeu; Silva, Pedro Eduardo Almeida da; Vicenti, Juliano Rosa de Menezes

doi:10.1016/j.cdc.2019.100240

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…For example, in a previously published work, the structure of ligands demonstrated an extremely important role in the biological activity against Streptococcus pneumoniae. In that case, structural modifications were suggested to be crucial by both the experimental and simulated data to improve the enzymatic inhibition mechanisms (Gonçalves et al, 2019). The complexes coordinated with Co(II) and cobalt chloride hexahydrate demonstrated antifungal activity at the concentration range of 64-128 μg/mL and 32-128 μg/ mL, respectively, against all Sporothrix isolates, without any significant difference among fungal species (Table I).…”

Section: Discussionmentioning

confidence: 99%

In vitro susceptibility of Sporothrix spp. to complexes coordinated with Co(II) and cobalt chloride hexahydrate

Brandolt

Klafke

Ramos

et al. 2022

Braz. J. Pharm. Sci.

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Sporothrix spp. are the major dimorphic fungus associated with a type of subcutaneous mycosis, sporotrichosis. The limitation of antifungal availability and the past reports of in vitro resistance of Sporothrix spp. clinical isolates makes it important to search for new compounds with antifungal activities. In this study, we therefore evaluate the in vitro activities of complexes coordinated with Co(II) and cobalt chloride hexahydrate against clinical isolates of Sporothrix spp. Broth microdilution test was performed as per M38-A2 from CLSI (2008) in duplicate for 31 clinical isolates of Sporothrix spp. (27 S. brasiliensis e 04 S. schenckii stricto sensu). The antifungal activities of the complexes coordinated with Co(II) and cobalt chloride hexahydrate were detected at a concentration range of 32-128 µg/mL for all isolates. None of the compounds demonstrated any cytotoxicity (to macrophage cells) at the concentration of 200 µg/mL. The activity against Sporothrix spp. recorded in this study instigate the continuity of experimental studies with Co(II) to search for the mechanisms of antifungal action as well as to evaluate its interaction with the commercial antifungal drugs.

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Section: Discussionmentioning

confidence: 99%

In vitro susceptibility of Sporothrix spp. to complexes coordinated with Co(II) and cobalt chloride hexahydrate

Brandolt

Klafke

Ramos

et al. 2022

Braz. J. Pharm. Sci.

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“…Suitable single crystals of the title compound were obtained within one week from a dimethylsulfoxide solution containing [Zn(NBZH) 2 ]Á2H 2 O, previously reported by us (Gonçalves et al, 2019). 1175 2Symmetry codes: (i) Àx þ 1; Ày þ 1; Àz þ 1; (ii) Àx þ 1; Ày þ 2; Àz þ 2; (iii) x þ 1; y; z.…”

Section: Synthesis and Crystallizationmentioning

confidence: 99%

trans-Bis(dimethyl sulfoxide-κO)bis(3-nitrobenzohydroxamato-κ² O,O′)zinc(II)

et al. 2019

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Single crystals of the title complex, [Zn(C7H5N2O4)2(C2H6OS)2] or [Zn(NBZH)2(DMSO)2], were isolated from a dimethyl sulfoxide (DMSO) solution containing [Zn(NBZH)2]·2H2O (NBZH = 3-nitrobenzohydroxamate anion). The asymmetric unit comprises of one O,O′-chelating NBZH anion, one O-bound DMSO ligand and one zinc(II) cation localized on an inversion centre. The three-dimensional crystal packing includes N—H...O and C—H...O hydrogen bonding, as well as O...H and H...H contacts identified by Hirshfeld isosurface analysis.

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Synthesis, characterization and evaluation of antimicrobial potential of zinc(II) complexes of nitro-substituted hydroxamic acid chelators

Sharma

Kumari

et al. 2022

Journal of Coordination Chemistry

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Synthesis, modeling and biological activity of new zinc(II) hydroxamates against streptococcus pneumoniae

Cited by 4 publications

References 30 publications

In vitro susceptibility of Sporothrix spp. to complexes coordinated with Co(II) and cobalt chloride hexahydrate

In vitro susceptibility of Sporothrix spp. to complexes coordinated with Co(II) and cobalt chloride hexahydrate

trans-Bis(dimethyl sulfoxide-κO)bis(3-nitrobenzohydroxamato-κ² O,O′)zinc(II)

Synthesis, characterization and evaluation of antimicrobial potential of zinc(II) complexes of nitro-substituted hydroxamic acid chelators

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Synthesis, modeling and biological activity of new zinc(II) hydroxamates against streptococcus pneumoniae

Cited by 4 publications

References 30 publications

In vitro susceptibility of Sporothrix spp. to complexes coordinated with Co(II) and cobalt chloride hexahydrate

In vitro susceptibility of Sporothrix spp. to complexes coordinated with Co(II) and cobalt chloride hexahydrate

trans-Bis(dimethyl sulfoxide-κO)bis(3-nitrobenzohydroxamato-κ2 O,O′)zinc(II)

Synthesis, characterization and evaluation of antimicrobial potential of zinc(II) complexes of nitro-substituted hydroxamic acid chelators

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Product

Resources

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trans-Bis(dimethyl sulfoxide-κO)bis(3-nitrobenzohydroxamato-κ² O,O′)zinc(II)