Synthesis, mobility study and antimicrobial evaluation of novel self‐spreading ionic silicone oligomers

Abstract

Polydimethylsiloxanes (PDMS) have been extensively utilized for their ability to spread and lubricate surfaces. This ability can be mostly attributed to their low surface energy and extremely flexible backbone. This study examines their unique ability through a comparative analysis of the rates of spread of numerous commercially available oils and lubricants, including a series of methylterminated PDMS. The analysis facilitated the design and synthesis of two homologous series of PDMS, in which the terminal ends were functionalized as quaternary ammonium salts. The two new series of compounds were examined for their ability to spread both as neat liquids and as formulated blends. Additionally, these hybrid ionic oligomers were screened for biological activity against Staphylococcus aureus. All of the new oligomers exhibited antimicrobial properties in preliminary testing.

Synthesis and biocidal efficacy of self‐spreading polydimethylsiloxane oligomers possessing oxyethylene‐functionalized quaternary ammoniums

“…Polydimethylsiloxanes (PDMS) have been utilized in a variety of applications due to their unique physical properties including low surface energy, the ability to wet a variety of surfaces, chemical inertness, low dielectric constants and low coefficients of friction 9–12. Furthermore, methyl terminated PDMS have previously been reported to have a high rate of spread in comparison to other liquids such as vegetable oil, motor oil and water 13. This observation is attributed to a combination of low surface energy and flexible siloxane backbone.…”

Biocides for the Battlefield - Interim Report

“…34 Our interest lies in the synthesis, characterization and evaluation of custom antimicrobial compounds designed for both high biocidal activity at the surface against a variety of pathogens and compatibility with commercial carrier liquids and common polymer resins. 1 In this current work, a polyurethane hydrogel was chosen as the polymer matrix due to its exceptional versatility and unique water absorption characteristics, and the specific urethane hydrogel employed is capable of absorbing from 5 to 25% water by weight. The phenolic biocidal compounds possess polar polyether segments to promote water-solubility and resin compatibility along with non-polar alkyl chains to promote orientation and present the phenolic OH at the air-surface interface.…”

“…Through several previous work units, a significant synthetic undertaken was made in preparation of a variety of novel highly mobile biocides possessing low surface energies. [1][2][3][4] In addition, significant achievement in synthesis of novel classes of biocides were made, with the subsequent incorporation of these molecules into a variety of hydrogel coating systems. [5][6][7] Further exploration of amphiphilic molecules to achieve surface modification has also been undertaken in low loading conditions.…”

Self-Cleaning Photocatalytic Polyurethane Coatings Containing Modified C60 Fullerene Additives

“…Antimicrobial coatings have been successfully created by imparting additives such as nonionic biocides [4], quaternary ammonium biocides [5,6], surface concentrating biocides [7], functionalized coatings [8,9], and antimicrobial peptides [10]. While these are successful biocidal additives, less success has been achieved in chemical decontaminating coatings.…”