Synthesis, mechanical properties and biocompatibility of novel biodegradable Poly(amide-imide)s for spinal implant

Zou, Qiying; Zhou, Qian; Dai, Hongyue

doi:10.1016/j.polymdegradstab.2016.11.019

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…Finally, the reaction product was washed 3 times with 1 mol/L hydrochloric acid aqueous solution. Suction filtration and vacuum drying at 30 °C for 12 h were performed to obtain L-phenylalanine-based imide diacid monomer [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

“…The reason is that amino acids can endow the polymer materials with bioactive sites similar to peptide materials, and also provide enzymatic hydrolysis sites for the biodegradation of polymers [ 10 , 11 , 12 ]. In our previous research [ 13 ], the synthesized PAI derived from L-phenylalanine showed good biocompatibility, biodegradability, and potential application value in the field of biological materials. However, the hydrophilicity of PAI is poor.…”

Section: Introductionmentioning

confidence: 99%

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Polyoxyethylene Diamine Modification of Poly(amide-imide)-polyethylene Glycol Exhibits Excellent Hydrophilicity, Degradability, and Biocompatibility

Chen

et al. 2022

Polymers

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We designed and synthesized the polyoxyethylene diamine (H2N-PEG-NH2) and poly(amide-imide)-polyethylene glycol (PAI-PEG) copolymers. The physical and chemical properties, mechanical properties, and in vitro biocompatibility of the materials were characterized. The results showed that the best elongation at break and recovery were obtained when the amount of PEG was 5 wt%. With the increase in PEG content, the degradation rate, hydrophilic property, tensile strength and tensile modulus of the copolymer decreased to a certain extent. The material had the best thermal stability and mechanical properties when 5 wt% PEG was added. Cytocompatibility evaluation showed that the addition of PEG could enhance the cell compatibility of the material and make it potentially suitable for application in bone repair.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyoxyethylene Diamine Modification of Poly(amide-imide)-polyethylene Glycol Exhibits Excellent Hydrophilicity, Degradability, and Biocompatibility

Chen

et al. 2022

Polymers

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“…Its biomedical application has been recently probed in bioimaging and drug delivery 12,13 . In our previous study, the L‐phenylalanine derived PAI (PAI 2c) was designed, synthesized, and exhibited better hydrophilicity, degradability, mechanical flexibility, and biocompatibility than those of the PAI 2c, 14,15 but lack of suitable niche and regenerative microenvironment limited the further application in tissue regeneration. In fact, it is still a challenge to get a good balance between biological activity and mechanical prosperity.…”

Section: Introductionmentioning

confidence: 99%

The effect of silicon groups on the physicochemical property and bioactivity of L‐phenylalanine derived poly(amide‐imide)

Zhang

Zou

et al. 2023

J Biomed Mater Res

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Poly(amide‐imide) (PAI), serving as a synthetic polymer, has been widely used in industry for excellent mechanical properties, chemical resistance and high thermal stability. However, lack of suitable cell niche and biological activity limited the further application of PAI in biomedical engineering. Herein, silicon modified L‐phenylalanine derived poly(amide‐imide) (PAIS) was synthesized by introducing silica to L‐phenylalanine derived PAI to improve physicochemical and biological performances. The influence of silicon amount on physicochemical, immune, and angiogenic performances of PAIS were systemically studied. The results show that PAIS exerts excellent hydrophilic, mechanical, biological activity. PAIS shows no effects on the number of macrophages, but can regulate macrophage polarization and angiogenesis in a dose‐dependent manner. This study advanced our understanding of silicon modification in PAI can modulate cell responses via initiating silicon concentration regulation. The acquired knowledge will provide a new strategy to design and optimize biomedical PAI in the future.

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“…Therefore, more and more biodegradable polymers are starting to become a concern for people, especially a polymer that could control the rate of degradation [5,6]. Amino acid-based polyamide-imides (PAIs) are a type of high-performance (HP) materials that combine the thermal resistance and mechanical properties of polyimides, and the easy machinability of PA [7,8], as well as having improved degradation properties [9] and cell compatibility [10]. This is due to the introduction of natural chiral sections, which is obviously of great significance for the development of HP, high-processability, and biodegradable polymer materials.…”

Section: Introductionmentioning

confidence: 99%

Study on the Thermal Properties and Enzymatic Degradability of Chiral Polyamide-Imides Films Based on Amino Acids

Liu

Yang

et al. 2019

Applied Sciences

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Six kinds of chiral polyamide-imides (PAI3a-3f) have successfully been synthesized via direct polycondensation. The thermal properties of the materials were evaluated by the gravimetric analysis (TGA) and differential scanning calorimetry (DSC). A thermal test was conducted and showed that the polymers have good thermal stability. The Tg values were affected by the volume effect of the side groups, the internal plasticizing effect and the isolation effect. Polyamide-imides (PAIs) with L configuration showed higher Tg values than PAIs with D configuration. In the enzymatic degradation experiments of PAI films, the results showed that the structure of amino acids have the greatest influence on the degradation performance of PAIs relative to chirality. The PAI films with simple side groups and L configurations were easier to degrade. The degradation rate of natural chiral PAIs were higher than those of non-natural chiral PAIs. This makes it possible to develop polymer materials with specific degradation rates.

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Synthesis, mechanical properties and biocompatibility of novel biodegradable Poly(amide-imide)s for spinal implant

Cited by 7 publications

References 38 publications

Polyoxyethylene Diamine Modification of Poly(amide-imide)-polyethylene Glycol Exhibits Excellent Hydrophilicity, Degradability, and Biocompatibility

Polyoxyethylene Diamine Modification of Poly(amide-imide)-polyethylene Glycol Exhibits Excellent Hydrophilicity, Degradability, and Biocompatibility

The effect of silicon groups on the physicochemical property and bioactivity of L‐phenylalanine derived poly(amide‐imide)

Study on the Thermal Properties and Enzymatic Degradability of Chiral Polyamide-Imides Films Based on Amino Acids

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