Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines

Abstract

Background and aimsSynthesis of new potential antimicrobial agents and evaluation of their lipophilicity.MethodsTen new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.ResultsThe lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.ConclusionsWe have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity.

Lipophilicity evaluation of some thiazolyl‐1,3,4‐oxadiazole derivatives with antifungal activity

“…Therefore, the first component will be uncorrelated with the second component. For a better interpretation of the information, the matrices are graphically plotted in order to obtain a 2D plot and loading scores, which allows us to represent the relative position of the objects of the original variables (Ionuț, Tiperciuc, & Oniga, ; Onișor, Palage, & Sârbu, ; Palage et al, ; C. I. Stoica et al, ; Tiperciuc & Sârbu, ). PCA was performed using the XL‐STAT extension (XLSTAT, ).…”

“…The second component will account for the maximal amount of variance in the dataset that did not display strong correlation with the first component. Therefore, the first component will be uncorrelated with the second component.For a better interpretation of the information, the matrices are graphically plotted in order to obtain a 2D plot and loading scores, which allows us to represent the relative position of the objects of the original variables(Ionuț, Tiperciuc, & Oniga, 2017;Onișor, Palage, & Sârbu, 2010;Palage et al, 2011;C. I. Stoica et al, 2015;Tiperciuc & Sârbu, 2006).…”