Synthesis, Isomerization, and Antimicrobial Evaluation of Some Pyrazolopyranotriazolopyrimidine Derivatives

Abstract

6-Amino-5-imino-pyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine derivative 4 and pyrazolo-[4',3':5,6]pyrano[2,3-d]pyrimidin-5-ylhydrazine derivative 5 were prepared starting from 6-amino-3-methyl-4-(p-nitrophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 1. The synthesis and structure characterization of 9,11-dihydropyrazolo[4',3':5,6]pyrano[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to 9,11-dihydropyrazolo[4',3':5,6]pyrano[3,2-e] [1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions are reported. Moreover, the synthesis of 9,11-dihydropyrazolo[4',3':5,6]pyrano[3,2-e] tetrazolo[1,5-c]pyrimidine derivative 14 and N(9)-acyclic nucleoside 15 are described. Some of the prepared products showed potent antimicrobial activity.

Synthesis of New Thiazole, Bithiazolidinone and Pyrano[2,3-d]thiazole Derivatives as Potential Antimicrobial Agents

“…The minimum inhibitory concentration (MIC) measurement was determined for compounds with significant growth inhibition zones using twofold serial dilution method. [32] The MIC (µg/mL) and inhibition zone diameters values are presented in Table 1. The results depicted in Table 1 revealed that most of tested compounds displayed variable inhibitory effects on the growth of the tested Gram-positive and Gram-negative bacterial strains and also against antifungal strains.…”

Synthesis and characterization of new imidazolidineiminothione and bis-imidazolidineiminothione derivatives as potential antimicrobial agents

“…Minimum inhibitory concentration (MIC) of the most active synthesized compounds 3a, 5a and 5c was evaluated in vitro using the related reference [21]. The results of minimum inhibitory concentration were depicted in Table 2.…”

Synthesis, Tautomeric Structure, Dyeing Characteristics, and Antimicrobial Activity of Novel 4-(2-Arylazophenyl)-3-(2-hydroxyphenyl)-1-phenyl-2-pyrazolin-5-ones

“…The plates were incubated at 24 h at 37 ºC for bacteria and 48 h at 37 ºC for fungi. Compounds that showed signicant growth inhibition zones (>14 mm) using the twofold serial dilution technique, 31 were further evaluated for their minimal inhibitory concentrations (MICs).…”

“…The minimum inhibitory concentration (MIC) measurement was determined for compounds showed significant growth inhibition zones (>14 mm) using twofold serial dilution method. 31 The MIC (mg/ml) and inhibition zone diameters values are recorded in Table 4.…”