Synthesis, intermolecular interactions and biological activities of two new organic–inorganic hybrids C₆H₁₀N₂,2Br and C₆H₁₀N₂,2Cl·H₂O

Abstract

A slow evaporation method has permitted the crystallization of two novel crystals of (2-aminomethyl)pyridindiumdihalide C6H10N2,2Br (1) and C6H10N2,2Cl·H2O (2).

Physico‐Chemical Properties, Pharmacokinetics, Molecular Docking and In‐Vitro Pharmacological Study of a Cobalt (II) Complex Based on 2‐Aminopyridine

“…The energy difference between the frontier orbitals HOMO and LUMO can be used to predict the strength and stability of transition metal complexes [11,12] . A large number of metal transition complexes exhibit a broad spectrum of biological activities such as antitumor, antibacterial, antifungal, antiviral and antioxidant [4,13] . The use of in‐silico methods is widely applied in drug discovery; the synergy between biology, chemistry, physics and informatics helps identifying suitable drug target for medicinal applications [14,15] .…”

“…[11,12] A large number of metal transition complexes exhibit a broad spectrum of biological activities such as antitumor, antibacterial, antifungal, antiviral and antioxidant. [4,13] The use of in-silico methods is widely applied in drug discovery; the synergy between biology, chemistry, physics and informatics helps identifying suitable drug target for medicinal applications. [14,15] The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is categorized as a contagious disease emerged firstly in Wuhan in 2019 causing respiratory illness that may worsen in acute respiratory distress syndrome that might lead to death.…”

New Low-Dimensional Lead-Free Perovskite (2-AMP)2BiX7·H2O (X = Cl, Br) Crystals: Synthesis, Stability, and Nonlinear Optical Properties

“…Therefore, two new low-dimensional lead-free perovskite bulk crystals, (2-AMP) 2 BiX 7 ·H 2 O (2-AMP = 2-amine-methylpyridinium; X = Cl, Br), with NSC structures and high stability were prepared using a slow evaporation method. It should be pointed out that in virtue of 2-AMP cations, lots of compounds with perovskite − and non-perovskite structures − have been reported. However, only (2-AMP)­SbI 5 and (2-AMP)­(ClO 4 ) 2 demonstrate NCS structures; their ferroelectric properties are systematically studied, whereas the detailed investigations on NLO properties are limited.…”

An Investigation of Two Cu (II)‐Based Hybrid Materials: Physico‐Chemical Characterization, Theoretical Calculation and Evaluation of The Inhibitory Activities against Key Enzymes related to Diabetes and Obesity

“…Indeed, this compound dose‐dependently inhibits the activity of α‐amylase, whose IC 50 is 91.11±5.3 μg/mL. In fact, diabetes caused by a rise in the metabolism of carbohydrates and is a major factor in the development of long‐term diabetic complications by digestives enzymes as α‐amylase and α‐glucosidase [8–10,40–42] . Digestive enzymes for carbohydrates are located in the intestinal brush border.…”

“…Hybrid materials are organized differently from other artificial ways. The cohesion in the solid state between the different parts (organic and inorganic) is achieved by different interactions, such as hydrogen bonding, [8] π⋅⋅⋅π interactions which exist with two main types [9] and halogen–halogen interactions in organic compounds [10] . In these hybrids, the organic part may essentially have non‐linear optical properties [11] .…”