Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with norcantharidin and benzimidazole derivatives

Dynamics of Transition Metal and their Application in Biomedical Industry

“…Overall, the antimicrobial activity of the complexes is in the following order: Cu>Co>Ni>Zn. The dominance of the metal complexes may possibly be as a result of increased lipophilic nature of the complexes attributed to chelation and heteroatoms present in the ligand moiety [36,37,38].…”

Selected Pharmacological Applications of 1<sup>st</sup> Row Transition Metal Complexes: A review

“…Among the non-covalent binding modes, intercalation, groove binding and external electrostatic binding, intercalation is the most important one because it invariably leads to cellular degradation. Humungous reports are available throughout the literature regarding the interactions of V(IV), Ni(II), Co(II), Cu(II) and Zn(II) complexes with DNA and still now many research groups have actively involved in this field [141][142][143]. Among the research groups, most of them are concentrating only copper Schiff-base complexes.…”

A Study on Spectro-Analytical Aspects, DNA – Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic Activities, Antibacterial and Docking Properties of 3 – (1 – (6 – methoxybenzo [d] thiazol – 2 – ylimino) ethyl) – 6 – methyl – 3H – pyran - 2, 4 – dione and its Metal Complexes

“…The binding affinity of the metal complexes with CT-DNA was studied in tris (hydroxymethyl) aminomethane buffer (5 mM Tris-HCl, 50 mmole NaCl, pH: 7.2). A solution of CT-DNA in Tris-HCl buffer gives a ratio of UV absorbance at 250 nm and 260 nm of 1.8 : 1.0 to 1.9 : 1.0, indicating that the DNA was sufficiently free of protein [38]. The concentration of DNA per nucleotide was determined spectrophotometrically using molar absorptivity at 260 nm.…”