Synthesis, insecticidal, and fungicidal screening of some new quinoline derivatives

Abstract

This paper describes the synthesis of a series of quinolines graphted with hydrazones, pyrazoles, pyridazine, phthalazine, triazepinone, semicarbazide, and thiomorpholide moieties and four metal complexes. These derivatives were screened against Fusarium oxysporum and the red palm weevil (RPW) Rhynchophorus ferrugineus Oliver (coleopteran: Curculionidae) as palm pathogens. Only chlorinated quinolines were active against these organisms with hydrazones being good fungicides, while those modified with pyrazoles and pyrazines showed moderate insecticidal activity. A unique trihydroxylated hydrazone was active against both organisms, while another hydrazone, the most potent fungicide in this series, exhibited insecticidal activity only upon com- plexation with Zn2+ ions.

Photocatalytic Unsymmetrical Coupling of 2-Substituted Quinolines: Synthesis and Evaluation of the Antiplasmodial Potential of β-Norbenzomorphan Frameworks

“…Quinoline and its derivatives are among the important heterocyclic compounds . In the development of medicines and pesticides, quinoline motifs are highly important owing to their potential physiological properties such as antimalarial, antitumor, antioxidant, antiproliferative activities, and so forth. − Substituted quinolines are commonly faced in natural products, medicinal chemistry, and material chemistry. − Beside this, quinoline-based compounds are also used as an intermediate in the total synthesis for designing various important synthetic compounds . Accordingly, many transition-metal-catalyzed C–H activation/functionalization methods have been explored including alkylation/alkenylation/arylation, − amidation, , nitration, and halogenation at different positions of the quinoline moiety.…”

Organometal-Free Arylation and Arylation/Trifluoroacetylation of Quinolines by Their Reaction with CF3-ynones and Base-Induced Rearrangement

“…Nevertheless, chemistry of quinoline is a still intensively developing branch of the modern organic chemistry because of widespread applications of quinoline derivatives . Thus, this type of heterocycle has found application as sensors, agrochemicals, materials for phosphorescent organic light-emitting diodes, ligands for transition metal complexes, and antifoaming agents in refineries . Quinoline scaffolds play a significant role in drug discovery, showing many types of biological activities such as antifungal, anticancer, anti-inflammatory, and antileishmaniasis actions .…”

A Green Synthetic Approach Towards One Pot Multi Component Synthesis of Hexahydroquinoline and 9‐Arylhexahydroacridine‐1,8‐dione Derivatives Catalyzed by Sulphonated Rice Husk

“…[21,22] Along with these, this heterocyclic moiety have vast application in agricultural field also. [23] Many recent research works are carried on this unique heterocyclic motif due to its diverse biological activity. [24][25] Several homogeneous and heterogeneous catalysts have been employed for the synthesis of substituted hexahydroquinolines derivatives.…”

“…Many heterocyclic, [25] compounds containing the quinoline nucleus display anti‐inflammatory activity and they serve as antagonist inhibitors [20] . Quinolines with 1,4‐Dihydropyridine (DHP) nucleus have been found efficient in cardiovascular diseases as calcium channel blockers [21,22] . Along with these, this heterocyclic moiety have vast application in agricultural field also [23] .…”

“…Quinolines with 1,4‐Dihydropyridine (DHP) nucleus have been found efficient in cardiovascular diseases as calcium channel blockers [21,22] . Along with these, this heterocyclic moiety have vast application in agricultural field also [23] . Many recent research works are carried on this unique heterocyclic motif due to its diverse biological activity [24–25] …”