Synthesis, in vitro evaluation of antibacterial, antifungal and larvicidal activities of pyrazole/pyridine based compounds and their nanocrystalline MS (M = Cu and Cd) derivatives

New Reaction Products of Acetylacetone with Semicarbazide Derivatives

“…The use of Alk-and Ar-substituted semicarbazides corroborated the direct relationship between the structure of the resultant compounds and the basicity of the starting semicarbazide. Although semicarbazides are much stronger bases and nucleophiles than amines because of the additional supply of electrons to the nitrogen atom from adjacent NH 2 groups, it can be hypothesized consistently with basicity constant K b of amines that dimethylsemicarbazide ( 16) is the strongest base, while methylsemicarbazide (17) has a lower basicity, and phenylsemicarbazide (18) is weaker than semicarbazide. It was found by conducting similar reactions with these compounds (Scheme 5) that phenylsemicarbazide 18 when reacted with acetylacetone in the aqueous medium produces N-anilinocarbonyl-3,5-dimethyl-1-pyrazole carboxamide in 24 h (19).…”

“…Crystal Data for 15. C 12 H 16 N 6 O 2 , Mr = 276.31, monoclinic system, space group C2/c, a = 32.0854 (18) Synthetic Methods. The starting 4-nitrosemicarbazide (1) was prepared by the reported procedure.…”

“…15 More specifically, 3,5-dimethylpyrazole was found to exhibit antidiabetic 16 and antipyretic 17 actions, and the use of pyrazole derivatives as potent antibacterial drugs was described. 18 The use of drugs in the pyrazolic series such as Analgin and Antipyrine has become common practice.…”

“…In light of the aforesaid background, a logical question arises as to which compounds will be formed by the reaction between 4-nitrosemicarbazide and 1,3-dicarbonyl compounds since it is well known that the reaction of carbonic acid hydrazide derivatives (semicarbazide, 1,3-diaminourea, etc.) with 1,3-dicarbonyl compounds proceeds to give the respective hydrazones − and pyrazoles. − The pyrazole derivatives have been put to good use in practice because they possess diverse biological properties. − By now, pyrazole has proved to be the most useable framework from among all the known diazoles for screening in the field of pharmaceutical and medicinal chemistry . More specifically, 3,5-dimethylpyrazole was found to exhibit antidiabetic and antipyretic actions, and the use of pyrazole derivatives as potent antibacterial drugs was described .…”

“…with 1,3-dicarbonyl compounds proceeds to give the respective hydrazones − and pyrazoles. − The pyrazole derivatives have been put to good use in practice because they possess diverse biological properties. − By now, pyrazole has proved to be the most useable framework from among all the known diazoles for screening in the field of pharmaceutical and medicinal chemistry . More specifically, 3,5-dimethylpyrazole was found to exhibit antidiabetic and antipyretic actions, and the use of pyrazole derivatives as potent antibacterial drugs was described . The use of drugs in the pyrazolic series such as Analgin and Antipyrine has become common practice.…”