Synthesis, in vitro cytotoxicity and anti-platelet activity of new 1,3-bentzenedisulfonamides

Liu, Xiujie; Zhang, Zhihao; Deng, Qingsong; Chen, Xin; Wang, Chaoqing

doi:10.1007/s00044-019-02419-0

Cited by 3 publications

(1 citation statement)

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“…4 Alkylated anilines, and in particular ethyl anilines, represent important building blocks for the production of agrochemicals 5 and pharmaceuticals. 3,6 While the Buchwald–Hartwig amination is generally the method of choice for the preparation of aromatic amine derivatives, 7 it presents severe limitations including low tolerance toward functional groups (especially halides) and poor efficiency of the amination using NH 3 in the case of primary amines. 7,8 As a result, multistep approaches involving stoichiometric amounts of toxic reagents and waste are still commonly used.…”

Section: Introductionmentioning

confidence: 99%

Selective hydrodeoxygenation of acetophenone derivatives using a Fe₂₅Ru₇₅@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Selective hydrodeoxygenation of acetophenone derivatives using a Fe₂₅Ru₇₅@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

et al. 2022

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Synthesis, In Vitro Antiplatelet Activity of 4‐Ethoxy‐isophthalamides

Zhang

Wang

et al. 2020

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With the help of spatial quantitative structure‐activity relationships (QSAR) contour maps obtained by comparative molecular field analysis (CoMFA), a series of 4‐ethoxyisophthalamide compounds were prepared and some of them with higher activity were found. This paper continues the structural design, preparation, spectral confirmation of thirteen new 4‐ethoxyisophthalamide compounds and completes their preliminary screening of activity in response to the following inducers: adenosine diphosphate (ADP) and collagen. Among them, when ADP was used as an inducer, compounds whose activities are higher or close to picotamide, the IC50 value also were calculated and revealed that one compound 16 (IC50 : 0.26 μmol L−1) was more than three times more active than positive control drug picotamide. Meanwhile, cytotoxic effects in vitro of compound 11* and compound 16 on L929 cells were analyzed. The structure‐activity relationship showed that when electron‐withdrawing groups nitro or trifluoromethyl are introduced at the meta‐ or para‐ position of the two side chain benzene rings, it is beneficial on the whole to the improvement of antiplatelet activity.

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Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents

Liu

Wang

et al. 2021

Bioorganic & Medicinal Chemistry

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Synthesis, in vitro cytotoxicity and anti-platelet activity of new 1,3-bentzenedisulfonamides

Cited by 3 publications

References 14 publications

Selective hydrodeoxygenation of acetophenone derivatives using a Fe₂₅Ru₇₅@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Selective hydrodeoxygenation of acetophenone derivatives using a Fe₂₅Ru₇₅@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Synthesis, In Vitro Antiplatelet Activity of 4‐Ethoxy‐isophthalamides

Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents

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Synthesis, in vitro cytotoxicity and anti-platelet activity of new 1,3-bentzenedisulfonamides

Cited by 3 publications

References 14 publications

Selective hydrodeoxygenation of acetophenone derivatives using a Fe25Ru75@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Selective hydrodeoxygenation of acetophenone derivatives using a Fe25Ru75@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Synthesis, In Vitro Antiplatelet Activity of 4‐Ethoxy‐isophthalamides

Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents

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Selective hydrodeoxygenation of acetophenone derivatives using a Fe₂₅Ru₇₅@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines

Selective hydrodeoxygenation of acetophenone derivatives using a Fe₂₅Ru₇₅@SILP catalyst: a practical approach to the synthesis of alkyl phenols and anilines