Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

“…82 Other outstanding quinoline-based antidiabetic molecules are 68 with an IC 50 of 26.94 μg mL −1 , 83 69 with an IC 50 of 5.50 ± 0.10 μM, 84 70 with an IC 50 of 0.60 ± 0.01 μM (ref. 85) and 71 with an IC 50 of 0.002 ± 0.06 μM. 86 Their structures are shown in Fig.…”

Antimicrobial and anthelmintic activities of aryl urea agents

“…These findings are in line with those of prior studies. A study using trifluoromethoxy-substituted chalcone derivatives revealed potent antimicrobial activities against Gram-positive and Gram-negative bacteria [26] . For the future development of potent antimicrobial compounds derived from diphenyl urea or pyridyl-phenyl urea, introducing combinations of substitutions, such as aminoalkyl groups with trifluoromethoxy groups and/or chlorines, is promising.…”

Nematicidal Characterization of Newly Synthesized Thiazine Derivatives Using Caenorhabditis elegans as the Model Organism

“…Instruments. 1 HNMR and 13 CNMR spectra of all thiazine derivatives were performed via applying magnetic field at 500 and 125 MHz, respectively. A fluorescence microscope (Olympus BX-60 (USA)), an inverted microscope (Eclipse TS-100, Nikon, Japan), and quantitative RT-PCR (6321 Eppendorf, USA) were used in the current research.…”

“…Heterocyclic chemistry is a very rich field based on heterocyclic nuclei from natural and synthetic sources and therefore covers a major portion of organic compounds. Due to heterocyclic nuclei, it withstands the subject of medication and got more consideration in drug development. , Here in this context, we focused on thiazine and its derivatives owing to its therapeutic profile . Thiazine heterocyclic rings consist of nitrogen and sulfur atoms which exist at various positions in the ring, 1, 2- thiazine, 1, 3- thiazine, and 1,4- thiazine .…”