Synthesis, in vitro anthelmintic, and molecular docking studies of novel 5-nitro benzoxazole derivatives

Satyendra, R. V.; Vishnumurthy, K.A.; Vagdevi, H. M.; Dhananjaya, B. L.; Shruthi, A.

doi:10.1007/s00044-014-1207-6

Cited by 20 publications

(11 citation statements)

References 22 publications

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“…[66] 2.10 | Anthelmintic activity Anthelmintic is a class of drugs that leads to the expulsion of helminths or parasitic worms from the host body without causing any major damage. Satyendra et al (2015) prepared a series of facile 5-nitro-1, 3-benzoxazole derivatives. All the newly synthesized compounds were evaluated for anthelmintic activity against species Pheretima posthuma because of its similarity of internal structure and physical activities with round worm which is intestinal parasite of Homo sapiens.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Other compounds showed low activity in comparison to control albendazole with 0.5% concentration. [67] 2.11 | Analgesic activity Analgesics also called as painkillers are the class of drugs which provide relief from pain by acting on peripheral and central nervous system. The preparation of 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide derivatives was reported by Gautam et al (2014).…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Synthetic transformations and biological screening of benzoxazole derivatives: A review

Sattar

Mukhtar

Atif

et al. 2020

Journal of Heterocyclic Chem

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The presence of benzoxazole moiety in most of the heterocyclic compounds is well reported. The present literature review mainly highlights the novel synthetic transformation and describes the biological potential of most of the heterocyclic compounds by virtue of presence of benzoxazole framework. Most of the researchers have revealed that benzoxazole derivatives exhibit significant antibacterial, anti-inflammatory, antifungal, anticancer, analgesic, antiviral, anti-tubercular, and anthelmintic activities. Benzoxazole moieties also act as tyrosinase inhibitor and cholesterol ester transfer protein inhibitor. This literature review may provide an opportunity to the chemists to design new derivatives of benzoxazole that proved to be the successful agent in view of safety, effectiveness, and efficacy.

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

Synthetic transformations and biological screening of benzoxazole derivatives: A review

Sattar

Mukhtar

Atif

et al. 2020

Journal of Heterocyclic Chem

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“…The results of this study demonstrated that compounds 72 and 73 shown the potent anthelmintic properties. The researcher also performed molecular docking studies and concluded that the inhibition of b-tubulin target protein elite to the parasites is the principal mechanism behind the anthelmintic property of these synthesized compounds [94]. Structures of these synthesized compounds with antihelmintic property are presented in Fig.…”

Section: Anthelmintic Activitymentioning

confidence: 99%

Biological Potential of Benzoxazole Derivatives: An Updated Review

Uddin

Javed²,

Kumar³

2020

Asian J Pharm Clin Res

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Objective: Heterocycles exhibited an extensive role in the medicinal chemistry for the development of pharmaceutically active molecules. A heterocyclic scaffold is responsible for the therapeutic potential of majority of synthesized drug molecules. Therapeutic changes in the drug molecules related to the slight changes in the heterocyclic moiety. Benzoxazole and its derivatives showed potent and significant pharmacological activities. The main objective of our study is to impart updated information about synthesized benzoxazole derivatives and their biological potential against numerous diseases. Methods: A literature search was directed on the databases, namely, in MDPI, Science direct, PubMed, Springer, Taylor, and Francis by searching different keywords “Benzoxazole,” antimicrobial activity, anticancer activity, antitubercular, anti-inflammatory, analgesic, and anthelmintic activity. Conclusion: This review may radiate the path of researchers that are working to synthesized novel benzoxazole derivatives in the prospects of effectiveness and safety. Nonetheless, further in vivo and clinical studies are warranted on the potential derivatives of benzoxazole.

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“…The 2-substituted benzoxazoles and 2-substituted benzothiazoles are well-known substructures in a variety of biologically active natural compounds [1,2], photoluminescent materials [3,4] or pharmaceutical agents such as riluzole, a treatment for amyotrophic lateral sclerosis [5], zopolrestat, an aldose reductase inhibitor used for the treatment of diabetes mellitus [6], the antitumor agent phortress, which acts via binding to aryl hydrocarbon receptors [7], 2-phenylbenzo[d]oxazole-7-carboxamide derivatives which are potential Staphylococcus aureus sortase A Inhibitors [8], and so on [9,10] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly Syntheses of 2-Substituted Benzoxazoles and 2-Substituted Benzothiazoles from 2-Aminophenols, 2-Aminothiophenols and DMF Derivatives in the Presence of Imidazolium Chloride

et al. 2019

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A simple, economical and metal-free approach to the synthesis of 2-substituted benzoxazoles and 2-substituted benzothiazoles from 2-aminophenols, 2-aminothiophenols and DMF derivatives, only using imidazolium chloride (50% mmol) as promoter without any other additive, was reported. Various 2-substituted benzoxazoles and 2-substituted benzothiazoles were thus prepared in moderate to excellent yields.

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Synthesis, in vitro anthelmintic, and molecular docking studies of novel 5-nitro benzoxazole derivatives

Cited by 20 publications

References 22 publications

Synthetic transformations and biological screening of benzoxazole derivatives: A review

Synthetic transformations and biological screening of benzoxazole derivatives: A review

Biological Potential of Benzoxazole Derivatives: An Updated Review

Eco-Friendly Syntheses of 2-Substituted Benzoxazoles and 2-Substituted Benzothiazoles from 2-Aminophenols, 2-Aminothiophenols and DMF Derivatives in the Presence of Imidazolium Chloride

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