“…The most common linkage between the primary and secondary pharmacophores was mediated via an aliphatic linker that is terminated by an ether 585,588,602,605,616,617,620,656,701,763,768,788 or a secondary amide 473,479,489,515,516,583,602,700,776,785,788,799 bond. The aliphatic ether was further modified by adding a double bond, 788 a triple bond, an aromatic, cyclohexyl ring or a cyclopropyl rings, 584,800 or switched to a cyclic ether, 483,793,801 thio‐ether, 488,670,672 an aliphatic linker without any heteroatom 599,600,670,672,802 or an aromatic amine 478 .…”