Synthesis, Identification, Thermodynamic and Biological Studies of New Ligand Derivative from L-ascorbic acid and its Complexes with some Metal ions

Abstract

Reacting [O, O-2, 3-(chloro(carboxylic)methylidene)]-5, 6-isopropylidene-L-ascorbic acid with the L-proline gave new product "[O, O-2, 3-(N-carboxylic methylidene)-N-proline-5, 6-isopropylidene]-L-ascorbic acid (NCNPA)", that has been isolated and categorized through "1H, 13C-NMR, elemental analysis (C.H.N), mass spectroscopy, UV-Visible in addition to Fourier Transform infrared (FTIR) approaches". The complexes of (NCNPA) with metal ions, M2+ (Mn, Co, Ni, Cu, Zn, Cd, Hg) and Cr3+ have been produced and characterized through FTIR, UV-Vis., molar conductance, atomic absorption, magnetic susceptibility, elemental analysis (C.H.N) methods. The ratio of metal: ligand have been obtained was (1:1) for every complex. Studying thermodynamic functions (G, H, S) for the complexes at dissimilar temperatures the data indicated, that the reaction between metals ions and (NCNPA) was exothermic, spontaneous, and more random. The complexes have been proven stable and follow the Irving-Williams series that refers to an octahedral, and their stability decreases with increasing the temperature. The TLC for L(NCNPA) and complexes depicted one spot for each, indicating the purity of these compounds. All these compounds have been evaluated against dual kinds of humanoid pathogenic bacteria gram +ve and gram -ve.