Synthesis, identification, biological activity and anti-cancer activity Studies of Hetrocyclic Ligand Azo-schiff Base with Au(III) Complex

Abstract

This research involved preparation of 2-((E)-(1H-benzo.[d]imidazol-2-yl).diazenyl)-4-(((4-bromophenyl)imino)methyl)phenol and Au(III) complex which was prepared by mixing solution of metal salt with ligand solution at mole ratio[ M:L] 1:1 . Compounds prepared were identified by FT-IR,, elemental analyses (C.H.N). Molar conductance measurements, magnetic susceptibility UV-Visb. The biological activity of the compounds prepared were examined against the susceptible organisms Streptococcus, (Gram. Positive) and Escherichia coli ,(Gram .negative), as antibacterial and Penicillium. Sp and Aspergillus Niger as antifungal, The prepared compounds checked for anti-cancer activity; activity of anti-tumor against of breast cancer for human

Spectrophotometric Determination and Biological Activity Study of Zn(II) using a Newly Synthesized Azo Reagent Derivative from 4,5-bis(4-methoxyphenyl) Imidazole

“…Azo compounds are involved in some biological reactions, such as RNA and DNA inhibition, protein synthesis, and nitrogen fixation [8], they have many advantages, such as ease of preparation, abundant product, high selectivity and sensitivity, and desirable stability. These advantages make this class of chemicals highly used in different applications [9,10], and utilized successfully as anticancer-treating chemicals [11,12]. Zinc metal is an important component of the human body and a required cofactor for some intracellular proteins [13,14].…”