Synthesis , Identification And Evaluation Of Antibacterial Activity For Some New Heterocyclic Derivatives From 4-Methoxy-2-Nitroaniline

Abstract

This research involved synthesis. novel heterocyclic derivatives (quinazoline and thiazinone) derivatives , this compounds prepared from starting react (4-methoxy-2-nitroaniline) with 2,4-dimethoxyacetophenone to gate azo derivative (A) , (A) interact with aromatic amine derivatives to produce imine compounds (B1-B2), imine derivatives interact with (anthranilic acid , 2-mercaptobenzoic) to get heterocyclic derivatives quinazoline (C1-C2) and thiazinone (D1-D2 ) . All these compound characterized by13 C-NMR , FT-IR , 1HMNR . Then that,we studies the,biological,properties for,all heterocyclic derivatives,to,ward.two different kindof bacteria.

In vitro Anthelminitic, Antioxident Activity and In silico Adme Study of Synthesized Nitro benzimidazole Derivatives

“…Benzimidazole derivatives are reported as an active ingredient against antiviral 2 , antifungal 3 , anticancer 4 , anti-histaminic 5 antitubercular 6 , antiallergic 7 , antioxidant 8 antimicrobial 9 and antiulcer 10 , activities etc. Substituted benzimidazole derivatives especially at 2 nd and 5 th position 11 appears to be an important scaffold for anti-parasitic, anti-anthelmintic and medicine drugs 12 . 2-substituted benzimidazole derivative shows better anthelmintic activity against Indian earthworm 13 .…”