Synthesis, experimental spectra (IR &amp; Raman and NMR), vibrational analysis and theoretical DFT investigations of N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide

Aydın, Lütfiye; Şahan, Emine; Önal, Zülbiye; Özpozan, Talat

doi:10.1016/j.saa.2014.02.176

Cited by 4 publications

(1 citation statement)

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“…The treatment of infection still is a significant and challenging subject because of resistance to current therapeutic agents and emergence of infectious diseases . Pyrimidines as constituents of DNA and RNA represent diverse pharmacological agents as beneficial bactericides and fungicides . Thiazole ring unit as a common structural feature is employed in various pharmaceutically significant molecules .…”

Section: Introductionmentioning

confidence: 99%

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe₃O₄@l‐arginine and their biological investigation as potent antimicrobial agents

Afradi

Foroughifar

Pasdar

et al. 2016

Applied Organom Chemis

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Thiazolopyrimidine derivatives are well known because of their excellent therapeutic properties. In this investigation, an effective one‐pot three‐component method is described for the synthesis of novel 2‐[(Z)‐1‐(substituted phenyl)methylidine]‐7‐methyl‐3‐oxo‐5‐(substituted phenyl)‐2,3‐dihydro‐5H‐thiazolo[3,2‐a]pyrimidine‐6‐carboxilic acid tert‐butyl ester derivatives by condensation reaction of 3,4‐dihydropyrimidine‐2(1H)‐thiones, various aromatic aldehydes and chloroacetyl chloride under reflux conditions in the presence of Fe3O4@l‐arginine nanoparticles as a magnetically reusable and eco‐friendly catalyst with short reaction times and moderate yields. The chemical structures of all synthesized compounds were determined using infrared, 1H NMR and 13C NMR spectroscopies. In vitro antimicrobial activities of 3,4‐dihydropyrimidine‐2(1H)‐thiones and newly fused thiazolo[3,2‐a]pyrimidine derivatives were examined using the well diffusion method against diverse pathogenic strains, namely Staphylococcus aureus ATCC 6538, S. epidermidis ATCC 12228, Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 9027 (bacteria), Candida albicans ATCC 10231 (yeast) and Aspergillus niger ATCC 16404 (fungus). The compounds having 2‐hydroxy, 4‐hydroxy, 2‐chloro and 4‐chloro groups attached to the phenyl ring on the pyrimidine and 4‐CH3, 4‐OCH3 and 3‐NO2 groups attached to benzylidine on the thiazolo moiety showed significant antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe₃O₄@l‐arginine and their biological investigation as potent antimicrobial agents

Afradi

Foroughifar

Pasdar

et al. 2016

Applied Organom Chemis

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Synthesis, crystallography, DFT, MTT assay, and molecular docking studies of an exocyclic double-bonded crystalline chalcone

Michael

Priya

Sidharthan

et al. 2021

Chemical Data Collections

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Conformational analysis and vibrational spectroscopy of a paracetamol analogous: 2-Bromo-N-(2-hydroxy-5-methylphenyl)-2-methylpropanamide

Viana

Quintero

Viana

et al. 2017

Journal of Molecular Structure

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Synthesis, experimental spectra (IR & Raman and NMR), vibrational analysis and theoretical DFT investigations of N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide

Cited by 4 publications

References 40 publications

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe₃O₄@l‐arginine and their biological investigation as potent antimicrobial agents

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe₃O₄@l‐arginine and their biological investigation as potent antimicrobial agents

Synthesis, crystallography, DFT, MTT assay, and molecular docking studies of an exocyclic double-bonded crystalline chalcone

Conformational analysis and vibrational spectroscopy of a paracetamol analogous: 2-Bromo-N-(2-hydroxy-5-methylphenyl)-2-methylpropanamide

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Synthesis, experimental spectra (IR & Raman and NMR), vibrational analysis and theoretical DFT investigations of N-(5-(4-methylbenzoyl)-2-oxo-4-(4-methylphenyl)pyrimidine-1(2H)-yl)-4-methylbenzamide

Cited by 4 publications

References 40 publications

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe3O4@l‐arginine and their biological investigation as potent antimicrobial agents

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe3O4@l‐arginine and their biological investigation as potent antimicrobial agents

Synthesis, crystallography, DFT, MTT assay, and molecular docking studies of an exocyclic double-bonded crystalline chalcone

Conformational analysis and vibrational spectroscopy of a paracetamol analogous: 2-Bromo-N-(2-hydroxy-5-methylphenyl)-2-methylpropanamide

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Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe₃O₄@l‐arginine and their biological investigation as potent antimicrobial agents

Facile green one‐pot synthesis of novel thiazolo[3,2‐a]pyrimidine derivatives using Fe₃O₄@l‐arginine and their biological investigation as potent antimicrobial agents