Synthesis, Duplex-forming Ability and Fluorescent Property of OligoDNA Bearing Silylated Fluorophore

Shinozuka, Kazuo; Sekiguchi, Tohru; Ebara, Yumiko; Moriguchi, Tomohisa

doi:10.1093/nass/nrm004

Cited by 2 publications

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“…This may be an indicator of the adverse effect of the stabilization of the G-quadruplexes in telomeric regions. These structures can presumably form in transition states; however, the telomeres cannot permanently maintain the structure of G-quadruplexes [ 45 ].…”

Section: Telomere Structurementioning

confidence: 99%

Telomere Lengthening and Other Functions of Telomerase

et al. 2012

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Telomerase is an enzyme that maintains the length of the telomere. The telomere length specifies the number of divisions a cell can undergo before it finally dies (i.e. the proliferative potential of cells). For example, telomerase is activated in embryonic cell lines and the telomere length is maintained at a constant level; therefore, these cells have an unlimited fission potential. Stem cells are characterized by a lower telomerase activity, which enables only partial compensation for the shortening of telomeres. Somatic cells are usually characterized by the absence of telomerase activity. Telomere shortening leads to the attainment of the Hayflick limit, the transition of cells to a state of senescence. The cells subsequently enter a state of crisis, accompanied by massive cell death. The surviving cells become cancer cells, which are capable both of dividing indefinitely and maintaining telomere length (usually with the aid of telomerase). Telomerase is a reverse transcriptase. It consists of two major components: telomerase RNA (TER) and reverse transcriptase (TERT). TER is a non-coding RNA, and it contains the region which serves as a template for telomere synthesis. An increasing number of articles focussing on the alternative functions of telomerase components have recently started appearing. The present review summarizes data on the structure, biogenesis, and functions of telomerase.

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Section: Telomere Structurementioning

confidence: 99%

Telomere Lengthening and Other Functions of Telomerase

et al. 2012

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Effects of substituents in silyl groups on the absorption, fluorescence and structural properties of 1,3,6,8-tetrasilylpyrenes

Maeda

Suzuki

Segi

2018

Photochem Photobiol Sci

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1,3,6,8-Tetrasilylpyrenes and related germyl and stannyl derivatives were synthesized, and their absorption and fluorescence spectroscopic and structural properties were elucidated. The results show that the UV-vis absorption maxima of these substances in CH2Cl2 solutions shift to longer wavelengths as the size of the alkyl groups and numbers of phenyl groups on silicon increase. Fluorescence quantum yields of tetrasilylpyrenes in cyclohexane are larger than that of pyrene, and a pentamethyldisilyl derivative has an emission efficiency of 0.79. Except in the case of the SiMe2H derivative, excimer emission was not observed in concentrated solutions of these substances. The SiMe2H and SiMe3 derivatives were shown to form CT complexes with tetracyanoethylene in CH2Cl2 solutions. The calculated energy barriers for rotation of the silyl groups about the Si-C bond increase as the steric bulk of the silyl group increases. 29Si NMR chemical shifts were found to depend on the sizes of the alkyl groups and numbers of phenyl groups. Data arising from theoretical calculations suggest that the silyl groups act as electron-donating groups, and the donating ability of the groups decreases in the order SiR3 > GeR3 > SnR3.

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Synthesis, Duplex-forming Ability and Fluorescent Property of OligoDNA Bearing Silylated Fluorophore

Cited by 2 publications

References 0 publications

Telomere Lengthening and Other Functions of Telomerase

Telomere Lengthening and Other Functions of Telomerase

Effects of substituents in silyl groups on the absorption, fluorescence and structural properties of 1,3,6,8-tetrasilylpyrenes

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