Synthesis, Docking Studies and Evaluation of Chalcones as Anti‐Helicobacter pylori and antitumoral Agents
Jessica Rodrigues Pereira de Oliveira Borlot,
Luna Schlittler dos Santos,
Guilherme José Schwarzt Sampaio
et al.
Abstract:Helicobacter pylori colonizes the gastric epithelium of 50 % of world population and it is the main etiological agent of human chronic gastritis, peptic ulcer, and gastric cancer. In this study, we synthesized and characterized a series of 14 chalcones and evaluated their anti‐H. pylori, NO inhibition (in vitro and in silico), and AGS cells cytotoxic effects. Compounds 3b and 3h showed MIC of 8 μg/mL. We observed structure‐activity relationships, mainly related to the influence of methoxy substituent at C‐2 (3… Show more
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