Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel(ii) bis(thiosemicarbazone) complexes

Abstract

Cytotoxic nickel(ii) complexes with an N-substituted isatin thiosemicarbazone were synthesized and their interaction with CT DNA and BSA protein was investigated, which was supported by molecular docking studies.

Synthesis, Structural, Biological Evaluation, Molecular Docking and DFT Studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) Complexes bearing Heterocyclic Thiosemicarbazone ligand

“…It also has been known that the influence on the biological activity of the metal complexes can be brought about by the nature of the metal ion, its oxidation state, and the number and type of ligands bound to improve the potentiality of the drugs . We have been very much interested in studying the variable coordination behaviour of thiosemicarbazone ligands and their metal complexes towards various biological applications …”

Synthesis, spectral and quantum chemical studies and use of ( E )-3-[(3,5-bis(trifluoromethyl)phenylimino)methyl]benzene-1,2-diol and its Ni(II) and Cu(II) complexes as an anion sensor, DNA binding, DNA cleavage, anti-microbial, anti-mutagenic and anti-cancer agent

“…6c). The Kb values obtained for Schiff base, complexes Ni(II) and Cu(II) were 166, 3.49 and 3.55 M -1 respectively[61]. Consequently, the observation of hypochromic effect in the absorption spectra implies that the Schiff base and Ni(II) complex established an intercalative bond with DNA.…”

Transition Metal Intercalators as Anticancer Agents—Recent Advances

“…Nickel and zinc have also seen widespread use in medicinal chemistry as DNA nucleases due to their natural abundance in humans and important roles in cellular functions [77,78]. A recent zinc study focused upon complexes of 2,6- bis (1-phenyl-1 H -benzo[d]imidazol-2-yl)pyridine (bpbp) [77].…”

“…Another intercalating zinc complex of 5-bromo-8-hydroxyquinoline displayed higher cytotoxicity in BEL-7404 and T-24 cells than cisplatin and induced cell cycle arrest in the G 2 phase of the BEL-7404 cells [79]. A series of nickel isotin thiosemicarbazone complexes were also found to intercalate with DNA and achieve up to 99.8% cleavage of plasmid DNA without the addition of peroxide [78]. The lead compound, [Ni(L) 2 ] (where L = ( Z )-2-(1-benzyl-2-oxoindolin-3-ylidene)- N -methylhydrazinecarbothioamide, Ni1 , Figure 11) was highly active against MCF7 cells with an IC 50 value of <0.1 μM.…”