Synthesis, DNA interaction, topoisomerase I, II inhibitory and cytotoxic effects of water soluble silicon (IV) phthalocyanine and napthalocyanines bearing 1-acetylpiperazine units

Anticancer and biological properties of new axially disubstituted silicon phthalocyanines

“…However, the quaternized silicon phthalocyanines were similar to the related silicon phthalocyanines. 35 In addition, the biological measurements obtained for the new quaternized silicon phthalocyanines are compatible with the literature, despite the presence of the aggregated species in DMSO. [54][55][56] DNA cleavage activity DNA is a vital molecule for all living cells and it can be mutated, and in turn, threaten the living organisms.…”

“…As phthalocyanines exhibit efficient anticancer features, scientists have been interested in these new subtypes in recent years. [30][31][32][33][34][35][36][37][38][39] In addition, it is essential to know and understand the chemical structure of genomic DNA, which is located in the cell nucleus and has many crucial functions in the living system, to provide new drugs, because this will help us to understand the binding mechanism of many molecules, such as phthalocyanines, that will interfere with DNA and change its function in the desired direction. In the DNA the helix structure, phosphate skeleton, double helix, and sugar structure are the same in all living species, while the length of the DNA helix, the number of base pairs, the distance between the two helixes (width), the size of the major and minor grooves formed between the helixes, the number, and type of base pairs are different.…”

New phthalonitrile/metal phthalocyanine–gold nanoparticle conjugates for biological applications

“…The phthalocyanines displayed plasmid DNA cleavage ability. 62 In comparison to the literature, it was found that compounds 1–3 and NG-1–3 can be used as DNA targeting molecules in anticancer and antimicrobial studies after further investigations.…”

An Investigation upon DNA Interaction of 2 (3), 9 (10), 16 (17), 23 (24) –Tetrakis 4-(4-(2-phenylprop-2-yl) phenoxy) Phthalocyanine Compound

“…The hypochromicity that appeared proved that PcF binds to the DNA with intercalative mechanisms. It is accepted that redshift in absorption spectra is related to the decreasing of energy from HOMO to LUMO of the ring of phthalocyanine, but hypochromicity refers to the binding between chemical complexes and the bases of CT-DNA molecule [40][41][42]. The changing in hypochromicity indicates that PcF interacts by the DNA through the intercalation binding mechanisms.…”