Synthesis, DNA‐Inhibiting and Antitumor Activity of Thiosemicarbazones of 2‐Formyl‐2,5‐dimethoxy‐2,3‐dihydro‐4H‐pyran, Its Ethyl Analogue and Copper Complex.

Keiko, N. A.; Степанова, Л. Г.; Воронков, М. Г.; Потапова, Г. И.; Gudrtov, N. O.; Трещалина, Е. М.

doi:10.1002/chin.200303109

Cited by 2 publications

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“…α-Alkoxysubstituted acrylic systems generate a particular research interest, as they represent a key structural motif of many biologically active natural compounds [ 14 ]. In addition, some derivatives of α-alkoxysubstituted α,β-unsaturated aldehydes are known to possess DNA-inhibiting and antitumor activity [ 15 ]. α-Alkoxysubstituted α,β-unsaturated aldehydes are the chemical equivalents of methylglyoxal [ 16 ], a low molecular regulator of cell growth in animals, plants, and microbes [ 17 , 18 ].…”

Section: Synthesis Of α-Functionally Substituted αβ-Unsaturated Aldehydesmentioning

confidence: 99%

α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

2021

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α-Functionalized α,β-unsaturated aldehydes is an important class of compounds, which are widely used in fine organic synthesis, biology, medicine and pharmacology, chemical industry, and agriculture. Some of the 2-substituted 2-alkenals are found to be the key metabolites in plant and animal cells. Therefore, the development of efficient methods for their synthesis attracts the attention of organic chemists. This review focusses on the recent advances in the synthesis of 2-functionally substituted 2-alkenals. The approaches to the preparation of α-alkyl α,β-unsaturated aldehydes are not included in this review.

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Section: Synthesis Of α-Functionally Substituted αβ-Unsaturated Aldehydesmentioning

confidence: 99%

α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

2021

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Para toluenesulfonic acid-catalyzed one-pot, three-component synthesis of benzo[5,6]chromeno[3,2-c]quinoline compounds in aqueous medium

Orang

Soltani

Ebrahimi

et al. 2021

Heterocyclic Communications

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A new series of benzo[5,6]chromeno[3,2-c]quinoline derivatives were successfully synthesized using various arylglyoxal monohydrates, quinoline-2,4-dione, and β-naphthol in H2O:EtOH (2:1) as a green solvent in the presence of catalytic amounts p-toluenesulfonic acid as a mild catalyst under reflux conditions with high yields (83–92%). The reaction conditions were optimized in different solvents at variable thermal conditions, and the optimized reaction condition for this synthesis has been reported. The structures of all new products were defined by 1H-NMR, 13C-NMR, FT-IR, mass spectral data, and HRMS.

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Synthesis, DNA‐Inhibiting and Antitumor Activity of Thiosemicarbazones of 2‐Formyl‐2,5‐dimethoxy‐2,3‐dihydro‐4H‐pyran, Its Ethyl Analogue and Copper Complex.

Abstract: Complex. -(KEIKO, N. A.; STEPANOVA, L. G.; VORONKOV, M. G.; POTAPOVA, G. I.; GUDRTOV, N. O.; TRESHCHALINA, E. M.; Khim.-Farm. Zh. 36 (2002) 8, 11-13; Irkutskii inst. khim. im. Favorskogo, Sib. otd. Ross. Akad. nauk, Irkutsk 664033, Russia; Russ.) -Koehler 03-109

Cited by 2 publications

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α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

α-Functionally Substituted α,β-Unsaturated Aldehydes as Fine Chemicals Reagents: Synthesis and Application

Para toluenesulfonic acid-catalyzed one-pot, three-component synthesis of benzo[5,6]chromeno[3,2-c]quinoline compounds in aqueous medium

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