Synthesis, DNA-binding and photocleavage of “light switch” complexes [Ru(bpy)2(pyip)]2+ and [Ru(phen)2(pyip)]2+

Li, Xuewen; Shen, Youming; Lü, Jian; Chen, Yuandao; Li, Lin; Zhang, Dashun

doi:10.1016/j.saa.2010.06.030

Cited by 30 publications

(7 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The intrinsic binding constant K obtained for complex 1 is 2.4±0.1×10 5 M −1 (s=0.74). The value is smaller than that of the parent complexes, [Ru(bpy) 2 (dppz)] 2+ (3.2× 10 6 M −1 ) [48] and [Ru(bpy) 2 (pyip)] 2+ (5.3×10 5 M −1 ) [44]. Our previous report showed that [Ru(bpy) 2 (pyip)] 2+ exhibited lower DNA affinity than that of [Ru(bpy) 2 (dppz)] 2+ .…”

Section: Electronic Absorption Titrationmentioning

confidence: 79%

“…The compounds, [Ru(bpy) 2 (phendione)] 2 + [ 45], [Ru(bpy) 2 (pyip)] 2+ [44] and 2-(pyridine-2-yl)-5,6-diamino-1H-benzimidazole [15] were synthesized according to methods in the literature. Calf thymus DNA (CT-DNA) and ethidium bromide were purchased from Sigma (USA).…”

Section: Experimental Materialsmentioning

confidence: 99%

“…The Ru(II) complex, [Ru(bpy) 2 (pyidppz)] 2+ displayed resolvable 1 H NMR spectra (Fig. S1), and all proton chemical shifts were assigned based on the comparison with those of similar compounds [7][8][9][10][11][12][13][14][15][16][17][18][36][37][38][39][40][41][42][43][44]. A singlet peak for the complex appears at ca.13.9, which assigned to the proton on the nitrogen atom of the imidazole.…”

Section: Dna Strand Passage Assaymentioning

confidence: 99%

“…Our group has reported a ruthenium (II) complex [Ru(bpy) 2 pyip] 2+ [44] with Blight switch^property, whose emission is modulated by Co 2+ and EDTA. However, this complex emits strong luminescence in aqueous solution, and cannot exhibit DNA Bmolecular light switch^properties in the presence of only DNA.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit

et al. 2015

Self Cite

View full text Add to dashboard Cite

A new ruthenium complex with a dppz-like ligand pyidppz, [Ru(bpy)2(pyidppz)](2+) (pyidppz = 2-(pyridine-2-yl)imidazo-[4,5-b]dipyrido-[3,2-a:2',3'-c]phenazine) has been synthesized and characterized by ES-MS, elemental analysis, (1)H NMR. Intercalative mode of the complex bound to calf thymus DNA has been supported by different spectroscopic methods and viscosity measurements. The introduction of phenazine unit may be one of the main reasons for the weak emission of Ru(II) complex in aqueous solution. Under irradiation, this complex can efficiently cleave DNA. And the photocleavage reaction of the complex is found to be inhibited in the presence of singlet oxygen scavenger. Topoisomerase inhibition and DNA strand passage assay demonstrated that [Ru(bpy)2(pyidppz)](2+) and its parent complex [Ru(bpy)2(pyip)](2+) (pyip = 2-(pyridine-2-yl)imidazo[4,5-f][1,10]phenanthroline) can act as efficient catalytic inhibitor of DNA topoisomerase I.

show abstract

Section: Electronic Absorption Titrationmentioning

confidence: 79%

Section: Experimental Materialsmentioning

confidence: 99%

Section: Dna Strand Passage Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Compound 1 was obtained on the basis of the method for imidazole ring preparation established by Schaefer and Peters [33,34,42]. The diamino compound 2 was prepared by detosylation of the corresponding tosylated 1.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Synthesis, DNA-binding, and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand

Lü

et al. 2011

Journal of Coordination Chemistry

Self Cite

View full text Add to dashboard Cite

2011)Synthesis, DNA-binding, and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand, Journal of Coordination Chemistry, 64:24, 4344-4356,and its ruthenium complexes with [Ru(L) 2 pdpiq] 2þ (L ¼ bpy (2,2 0 -bipyridine) or phen (1,10-phenanthroline)) have been synthesized and characterized by elemental analysis, ES-MS, and 1 H NMR. The DNA-binding behaviors of these complexes were studied by spectroscopic methods and viscosity measurements. The results indicate that the complexes can intercalate into DNA base pairs. When irradiated at 365 nm, the two complexes promote the cleavage of plasmid pBR322DNA. The mechanism of DNA cleavage is an oxidative process by generating singlet oxygen.

show abstract

Cobalt(II)–metformin complexes containing α‐diimine/α‐diamine as auxiliary ligand: DNA binding properties

Vasantha

Kumar

Shekhar

et al. 2017

Applied Organom Chemis

View full text Add to dashboard Cite

The cobalt(II) complexes [Co(Cl)2(met)(o‐phen)] (1), [Co(Cl)2(en)(met)] (2) and [Co(Cl)2(met)(opda)] (3) (met = metformin, o‐phen = ortho‐phenanthroline, en = ethylenediamine, opda = ortho‐phenylenediamine) were synthesized and characterized using liquid chromatography–mass spectrometry, elemental analysis, molar conductance measurements, thermal analysis, infrared spectroscopy, magnetic moment measurements, electronic spectroscopy and X‐ray diffraction. The metal centre was found to be in an octahedral geometry. UV–visible absorption, fluorescence and viscosity measurements were conducted to assess the interaction of the complexes with calf thymus DNA. The complexes showed absorption hyperchromism in UV–visible spectra with DNA. The binding constants from UV–visible absorption studies were 1.38 × 105, 2.1 × 105 and 3.1 × 105 M−1 for 1, 2 and 3, respectively, and Stern–Volmer quenching constants from fluorescence studies were 0.146, 0.176 and 0.475, respectively. Viscosity measurements revealed that the binding of the complexes with DNA could be surface binding, mainly due to groove binding. The activities of the complexes in DNA cleavage decrease in the order 3 > 2 > 1. The complexes were docked into DNA topoisomerase II using Discovery Studio 2.1 software.

show abstract

Synthesis, DNA-binding and photocleavage of “light switch” complexes [Ru(bpy)2(pyip)]2+ and [Ru(phen)2(pyip)]2+

Cited by 30 publications

References 45 publications

DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit

DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit

Synthesis, DNA-binding, and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand

Cobalt(II)–metformin complexes containing α‐diimine/α‐diamine as auxiliary ligand: DNA binding properties

Contact Info

Product

Resources

About