Synthesis, crystal structures, luminescent properties, theoretical calculation, and DNA interaction of the cadmium(II) and lead(II) complexes with o-aminobenzoic acid and 1,10-phenanthroline

Zhang, Z. Y.; Bi, Caifeng; Yu, Fan; Yan, Xingchen; Zhang, Xing; Zhang, P. F.; Huang, Guimei

doi:10.1134/s1070328415030094

Cited by 8 publications

(3 citation statements)

References 35 publications

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“…Cd serves as a catalytic center in carbonic anhydrase [5]. Also, it has interesting DNA binding abilities [6][7][8], antibacterial activities [9,10] and antitumor properties [11,12] and is a known catalyst for organic transformations [13][14][15][16][17][18]. Also, Cd(II) compounds have many applications in photoluminescence and non-linear optics [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

X-ray Structures and Hirshfeld Studies of Two Dinuclear Cd(II) Complexes with a s-Triazine/Pyrazolo Ligand and Pesudohalides as a Linker

et al. 2023

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The two dinuclear Cd(II) complexes [Cd(BPMST)(SCN)]2 (1) and [Cd(BPMST)(N3)Cl]2 (2) of a s-triazine/pyrazolo ligand (BPMST) were synthesized. The preparation of both complexes was performed in a water–ethanol solvent mixture and involved the mixing of the functional ligand BPMST with CdCl2 in the presence of thiocyanate or azide as linkers, respectively. The dinuclear formula of both complexes and the involvement of the pesudohalide as a linker between the Cd(II) centers were approved by single crystal X-ray structures. The Cd(II) was hexa-coordinated and the CdN5S (1) and CdN5Cl (2) coordination environments had distorted octahedral geometry. In the [Cd(BPMST)(SCN)]2 and [Cd(BPMST)(N3)Cl]2, the BPMST acted as a pincer tridentate N-chelate. In the case of 1, the SCN¯ acted as a μ(1,3) bridging ligand between the Cd(II) centers, while the N3¯ had a μ(1,1) bridging mode in 2. As a result, the Cd…Cd distance was significantly longer in 1 (5.8033(5) Å) than in 2 (3.796(2) Å). In both complexes, the Cd(II) had distorted octahedral coordination geometry. Hirshfeld surface analysis was performed to inspect the supramolecular aspects of the two Cd(II) complexes. The C…H, N…H and S…H contacts were important in the case of [Cd(BPMST)(SCN)]2 (1). Their percentages were calculated to be 14.7, 17.0 and 13.4%, respectively. In the case of [Cd(BPMST)(N3)Cl]2 (2), the most significant contacts were the Cl…H, C…H and N…H contacts. Their contributions in the molecular packing were 16.5, 9.7 and 25.3%, respectively. The propensity of atom pairs of elements to form contacts in the crystal structure was analyzed using enrichment ratio (EXY).

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Section: Introductionmentioning

confidence: 99%

X-ray Structures and Hirshfeld Studies of Two Dinuclear Cd(II) Complexes with a s-Triazine/Pyrazolo Ligand and Pesudohalides as a Linker

et al. 2023

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“…The coordination compounds of Cd(II) have received increased attention due to their interesting structures and versatile applications in nanotechnologies [37][38][39][40]. Moreover, they have interesting DNA binding abilities [41][42][43], antibacterial activities [44,45], antitumor properties [46,47], and are known catalysts for organic transformations [48][49][50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

Molecular and Supramolecular Structures of Cd(II) Complexes with Hydralazine-Based Ligands; A New Example for Cyclization of Hydrazonophthalazine to Triazolophthalazine

et al. 2021

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Molecular and supramolecular structures of two polymeric and one trinuclear Cd(II) complex with hydralazine-type ligands were presented. Self-assembly of E-1-(2-(thiophen-2-ylmethylene)hydrazinyl)phthalazine (HL) and CdCl2 gave the 1D coordination polymer [Cd(H2L)Cl3]n*H2O, 1, in which the Cd(II) ion is hexa-coordinated with one cationic monodentate ligand (H2L+) and five chloride ions, two of them acting as connectors between Cd(II) centers, leading to the formation of a 1D coordination polymer along the a-direction. Using DFT calculations, the cationic ligand (H2L+) could be described as a protonated HL with an extra proton at the hydrazone moiety. Repeating the same reaction by heating under reflux conditions in the presence of 1 mL saturated aqueous KSCN solution, the ligand HL underwent cyclization to the corresponding [1,2,4]triazolo[3,4-a]phthalazine-3(2H)-thione (TPT) followed by the formation of [Cd(TPT)(SCN)2]n*H2O, 2, a 1D coordination polymer. In this complex, the Cd(II) is coordinated with one NS-donor TPT bidentate chelate and two bridged μ(1,3)-thiocyanate ions connecting the Cd(II) centers forming the 1D polymer array along the b-direction. Heating E-2-(1-(2-(phthalazin-1-yl)hydrazono)ethyl)phenol HLOH with CdCl2 under reflux condition gave the trinuclear complex [Cd3(Hydralazine)2(H2O)2Cl6], 3, indicating the hydrolysis of the hydrazonophthalazine ligand HLOH during the course of the reaction. Due to symmetry considerations, there are only two different Cd(II) centers having CdN2Cl3O and CdN2Cl4 coordination environments. Hirshfeld topology analysis was used to analyze the solid-state supramolecular structure of the studied complexes.

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“…Herein we report a new tetranuclear Pb(II) coordination cage synthesized with the 4-nitrobenzoic acid introduced into the system of Pb II /8-hydroxyquinoline. In recent years, a few Pb(II) complexes have been reported concerning their biological activities, such as DNA binding property (Gao et al, 2017;Li et al, 2008;Shen et al, 2016;Zhang et al, 2015), anticancer (Abd-Elzaher et al, 2012;Ghosh et al, 2017) and antimicrobial (El-Megharbel et al, 2014;Kurtaran et al, 2005;Pallikkavil et al, 2013;Ravichandran et al, 2014;Singh et al, 2010) activity. In this paper, in addition to the complex was characterized by elemental analysis, IR spectroscopy, and X-ray singlecrystal diffraction, as an attempt, the interaction between the complex, [Pb(8-OQ)(4-NB)], and DNA was investigated by UV absorption and fluorescence spectra, anticancer activity against MCF-7, HepG-2 and A549 cell lines of the complex was also tested by the MTT-based assay.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure, DNA binding and anticancer activity of a new tetranuclear Pb(II) complex constructed by 8-hydroxyquinolinate and 4-nitrobenzoate ligands

Liu

Xia

Cheng

et al. 2019

Main Group Metal Chemistry

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A new Pb(II) complex, [Pb(8-OQ)(4-NB)], where 8-OQ = 8-hydroxyquinolinate, 4-NB = 4-nitrobenzoate, has been synthesized and characterized by elemental analysis, IR spectroscopy, and X-ray single-crystal diffraction. The single crystal X-ray analysis reveals that the complex possesses a tetranuclear Pb4O4 cubane structure. The Pb(II) atom is coordinated by three triply bridging phenolic hydroxyl O atoms of 8-OQ ligands, then the tetranuclear Pb system is formed resulting in a tetrahedral cage. The interaction of complex with HS-DNA in Tris buffer was studied by UV−vis absorption spectrum and fluorescence ethidium bromide displacement experiment with an intrinsic binding constant of 1.52×104 M-1 and a linear Stern–Volmer quenching constant of 6.77×103 M-1. Anticancer activity against MCF-7, HepG-2 and A549 cell lines of complex was also determined by the MTT-based assay. The results showed the complex can inhibit proliferation of these three kinds of tumor cells and is less cytotoxic than cisplatin.

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Synthesis, crystal structures, luminescent properties, theoretical calculation, and DNA interaction of the cadmium(II) and lead(II) complexes with o-aminobenzoic acid and 1,10-phenanthroline

Cited by 8 publications

References 35 publications

X-ray Structures and Hirshfeld Studies of Two Dinuclear Cd(II) Complexes with a s-Triazine/Pyrazolo Ligand and Pesudohalides as a Linker

X-ray Structures and Hirshfeld Studies of Two Dinuclear Cd(II) Complexes with a s-Triazine/Pyrazolo Ligand and Pesudohalides as a Linker

Molecular and Supramolecular Structures of Cd(II) Complexes with Hydralazine-Based Ligands; A New Example for Cyclization of Hydrazonophthalazine to Triazolophthalazine

Synthesis, structure, DNA binding and anticancer activity of a new tetranuclear Pb(II) complex constructed by 8-hydroxyquinolinate and 4-nitrobenzoate ligands

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