Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes

Yılmaz, Veysel T.; Gocmen, Elif; İçsel, Ceyda; Cengiz, Murat; Süslüer, Sunde Yılmaz; Büyükgüngör, Orhan

doi:10.1016/j.jphotobiol.2013.12.014

Cited by 40 publications

(24 citation statements)

References 94 publications

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“…This marked degree of toxicity between this class of silver(I) complexes and cisplatin was previously reported (Ferreira et al 2015;Human et al 2015;Potgieter et al 2015). Furthermore, silver(I) saccharinate complexes with monophosphines (Yilmaz et al 2014) including silver(I) salicylic acid with triphenylphosphine (Poyraz et al 2011) showed improved cytotoxicity in malignant cells when compared to cisplatin. In addition, silver(I) acetate o-methoxyphenyl diphosphine and dicyclohexylphosphine complexes were significantly Fig.…”

Section: Biological Studiessupporting

confidence: 70%

Apoptosis-inducing ability of silver(I) cyanide-phosphines useful for anti-cancer studies

2017

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Metal-based drugs have shown early promise as anticancer agents suggesting the potential application of silver(I) complexes as apoptosis-inducing agents. The ability of a silver(I) cyanide containing phosphine complex to induce cell death was evaluated in both a malignant (SNO esophageal cancer) and non-malignant (HDF-a skin and HEK293 kidney) cell lines. A dose-dependent decrease in cell viability was observed in the SNO cells. Light microscopy revealed morphological features indicative of apoptotic cell death. The mode of cell death was confirmed as apoptosis by phosphatidylserine externalization, DNA fragmentation and nuclear condensation. Furthermore, both the non-malignant cell lines showed morphological features indicative of apoptosis when exposed to complex 1. We propose the use of this silver(I) cyanide phosphine complex as an highly effective positive apoptosis control for use in anticancer studies of phosphine complexes.

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Section: Biological Studiessupporting

confidence: 70%

Apoptosis-inducing ability of silver(I) cyanide-phosphines useful for anti-cancer studies

2017

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“…The ability of the used Pt(II) complexes and cisplatin to bind gDNA from P. aeruginosa was examined by agarose gel electrophoresis as previously described. 62 Briefly, for the gel electrophoresis experiments, gDNA (500 ng) was treated with the tested compounds (25 µg mL −1 ) in phosphate buffer ( pH 7.4), and the contents were incubated for 12 h at 37°C, then subjected to gel electrophoresis on 0.8% (w/v) agarose gel containing 0.1 µg mL −1 of ethidium bromide in TAE buffer (40 mM Tris acetate/1 mM EDTA, pH 7.4) buffer at 60 V for 2 h. Gels were visualized and analyzed using a Gel Doc EZ system (Bio-Rad, Life Sciences, Hercules, USA) equipped with the Image Lab™ software.…”

Section: In Vitro Dna Binding By Gel Electrophoresis Assaymentioning

confidence: 99%

A new class of platinum(ii) complexes with the phosphine ligand pta which show potent anticancer activity

Živković

Kljun

Ilić-Tomič

et al. 2018

Inorg. Chem. Front.

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The anticancer potential of sixteen platinum(II) complexes with general formulae [PtCl(hq)(S-dmso)] (1a-8a) and [PtCl(hq)(pta)] (1b-8b) (where hq is 5-chloro-7-iodo-8-quinolinol (clioquinol; cqH) (1a, 1b), 8-hydroxy-5-nitroquinoline (nitroxoline; nxH) (2a, 2b), 5,7-dichloro-8-quinolinol (3a, 3b), 5,7-diiodo-8-quinolinol (4a, 4b), 5,7-dibromo-8-quinolinol (5a, 5b), 5,7-dichloro-8-hydroxy-2-methyl-quinoline (6a, 6b), 8-hydroxyquinoline (7a, 7b) and 8-quinolinethiol (8a, 8b); dmso is dimethyl sulfoxide and pta is 1,3,5-triaza-7-phosphaadamantane) was determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and A549) and embryotoxicity assay in a zebrafish model. Interactions with double stranded DNA through in vitro assay and a molecular docking study were examined. All complexes, except 6a, exhibited a high cytotoxic effect on MRC5 cells at a concentration of 10 µg mL −1 while 1b, 5a, 6a and 3b showed selective toxicity towards carcinoma cell lines. In general, were 1b, 3b, 6b and 5b. From observations of the DNA interaction ability and of the in silico assessment, no apparent DNA fragmentation was observed either on DNA extracted from the treated cancer cell line or from the zebrafish embryos.

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“…Non-covalent DNA interactions include intercalative, electrostatic and groove (surface) binding of cationic metal complexes. 50 The Ag1-4 and Ag1-5 complexes exhibited pronounced ability to competitively intercalate double stranded bacterial genomic DNA, which results in the inability of ethidium bromide to intercalate and emit under UV exposure ( Fig. 3a and b).…”

Section: Antimicrobial and Cytotoxic Properties Of Au1-5 And Ag1-5 Comentioning

confidence: 99%

A comparative antimicrobial and toxicological study of gold(iii) and silver(i) complexes with aromatic nitrogen-containing heterocycles: synergistic activity and improved selectivity index of Au(iii)/Ag(i) complexes mixture

et al. 2016

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Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes

Cited by 40 publications

References 94 publications

Apoptosis-inducing ability of silver(I) cyanide-phosphines useful for anti-cancer studies

Apoptosis-inducing ability of silver(I) cyanide-phosphines useful for anti-cancer studies

A new class of platinum(ii) complexes with the phosphine ligand pta which show potent anticancer activity

A comparative antimicrobial and toxicological study of gold(iii) and silver(i) complexes with aromatic nitrogen-containing heterocycles: synergistic activity and improved selectivity index of Au(iii)/Ag(i) complexes mixture

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