Synthesis, crystal structures and cytotoxicities of some transition metal complexes with N-[2-{(pyridin-2-ylmethylidene)amino}ethyl]acetamide

Synthesis and cytotoxic activities of chloropyridylimineplatinum(II) and chloropyridyliminecopper(II) surface-functionalized poly(amidoamine) dendrimers

“…Following up our previous work [9] on the synthesis of platinum (Pt) and copper (Cu) coordinated mono-nuclear compounds [(MeCONHCH 2 CH 2 N@CHPy)(PtCl 2 )] (1D) and [(MeCONHCH 2 CH 2 N @CHPy)(CuCl 2 )] (1E), we now report the synthesis, characterization and cytotoxicity of two novel multi-nuclear Pt and Cu complexes. In order to provide a good metal chelating ligand, first generation PAMAM dendrimers will be modified by reacting with [10][11][12] and cells of benign origin (Chang Liver).…”

“…Before the cytotoxic assays were conducted, the complexes 4D and 7E were first dissolved in absolute DMSO at a concentration of 1 Â 10 À2 M with 10% DMSO to the respective various concentrations of 1.25 Â 10 À4 M, 5 Â 10 À5 M, 2.0 Â 10 À5 M, 8.0 Â 10 À6 M, 3.2 Â 10 À6 M. Specific volumes of medium, cells and compounds were added into the respective wells of a 96-well microplate under sterile conditions. Cell culture procedures were similarly to what was reported previously [9]. Cisplatin was used as a reference.…”

“…The IC 50 values obtained are summarized in Table 4. The IC 50 values of 1L, 1D and 1E were cited from our previous publication [9] for comparison purposes.…”

“…In this study, cisplatin was used as a reference against these multi-nuclear complexes. For comparison purposes, the cytotoxicity of Pt and Cu mono-nuclear compounds are cited [9]. The differences in cytotoxicity on these cell lines induced by the variation of metals (i.e.…”

Crystal structure and biological activities of water-soluble nickel(II) and copper(II) complexes of a Schiff-base derived from paeonol

“…In recent years, Schiff-base metal complexes have also found important applications in the biological field [4][5][6][7][8]. Akitsu et al [9][10][11] have reported a large number of Schiff-base metal complexes and their crystal structures.…”