Synthesis, crystal structures and biological activity of palladium(II) complexes with 1-methyl-1H-1,2,3,4-tetrazole-5-thiol and substituted 2,2′-bipyridines

Rashidipour, Arezoo; Alizadeh, Robabeh; Mohammadi, Sanam Sadeghi; Tohidlou, Mohammad; Amani, Vahid; Seyfi, Sara

doi:10.1080/00958972.2020.1844883

Cited by 3 publications

(1 citation statement)

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“…The presence of two purine-like nucleobases led to the strongest inhibitory effect against the PDE3A, while the insertion of a pyrimidine-like nucleobase also led to an enhanced inhibitory effect against the PDE3A and cytotoxicity activity against the HeLa and MCF-7 cell lines. Rashidipour et al [ 63 ] reported the effectiveness of 60 on SKBR-3 cell proliferation as being similar to that of cisplatin, and the DNA-binding assay uncovered the ability of the compound to bind to DNA and alter its structure (see Figure 12 ).…”

Section: Five-membered Heterocyclic Compoundsmentioning

confidence: 99%

An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds

Ebenezer

Jordaan

Carena

et al. 2022

IJMS

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Heterocyclic compounds are a class of compounds of natural origin with favorable properties and hence have major pharmaceutical significance. They have an exceptional adroitness favoring their use as diverse smart biomimetics, in addition to possessing an active pharmacophore in a complex structure. This has made them an indispensable motif in the drug discovery field. Heterocyclic compounds are usually classified according to the ring size, type, and the number of heteroatoms present in the ring. Among different heterocyclic ring systems, nitrogen heterocyclic compounds are more abundant in nature. They also have considerable pharmacological significance. This review highlights recent pioneering studies in the biological assessment of nitrogen-containing compounds, namely: triazoles, tetrazoles, imidazole/benzimidazoles, pyrimidines, and quinolines. It explores publications between April 2020 and February 2022 and will benefit researchers in medicinal chemistry and pharmacology. The present work is organized based on the size of the heterocyclic ring.

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Section: Five-membered Heterocyclic Compoundsmentioning

confidence: 99%