Synthesis, crystal structures, and biological activities of silver(I) and cobalt(II) complexes with an azole derivative ligand

Abstract

Two new complexes, [Ag(L) 2 ](NO 3 ) Á (H 2 O)(1) and [Co(L) 2 Cl 2 ] (2) [L = 1-(imidazol-1-yl-methyl)-benzotriazole], have been synthesized and structurally characterized by X-ray diffraction techniques. In complex (1), the Ag(I) atom adopts a linear coordination geometry involving the imidazole nitrogens of two ligands. The [Ag(L) 2 ] units are developed into a three-dimensional structure by intermolecular hydrogen bonds, p-p interactions, and AgÁÁÁO interactions. In complex (2), the Co(II) atom is in a distorted tetrahedral environment with two imidazole nitrogens and two chloride ligands. The [Co(L) 2 Cl 2 ] units are assembled into a three-dimensional structure by intermolecular hydrogen bonds and p-p interactions. The bioactivities of both complexes have been studied, and the results indicate that complex (1) exhibits excellent radical-scavenging (RS) and fungicidal (FG) activities while complex (2) only has weak fungicidal activity.

Metal Complex Derivatives of Azole: a Study on Their Synthesis, Characterization, and Antibacterial and Antifungal Activities

“…19,20 Increased lipophilicity in the complexes reduces the permeability barrier of cells and slows normal cellular processes in microorganisms, resulting in increased antimicrobial activity. [19][20][21][22][23] With the aim of developing new antifungal and antibacterial compounds, we report the synthesis, characterization, and antibacterial and antifungal activities of metal complex derivatives of azoles. Four new zinc complexes were tested along with another two additional and previously reported complexes that contain copper and cobalt.…”

“…This finding is likely related to the better solubility, bioavailability, and interaction with DNA through intermolecular associations. 23,45 Also, it is possible that an increase in the lipophilicity of the complexes reduces the permeability barrier of the cells and slows the normal cellular processes of the microorganisms, resulting in increased antimicrobial activity. 36 The tested gram-positive strain was susceptible to all the metal complexes ( Figure 5).…”

Syntheses, structures and properties of two new isostructural zinc(II) complexes based on 1-[(benzotriazol-1-yl)methyl]-1H-imidazole

“…17 complexes and in a bridging mode in ten complexes (Duan et al, 2010a,b;Meng et al, 2009;Zhou et al, 2011;Wang & Sun, 2011;An et al, 2008;Hu et al, 2012;Huang et al, 2014;Zhang et al, 2015). In this work, the bmi ligands coordinate to the Zn II ion only via imidazole atom N1 in a monodentate mode, even though there are three potential N-atom donors in bmi.…”

“…Owing to the strong coordination ability and diversities of their coordination modes, N-heterocyclic organic compounds, such as imidazole, triazole, benzimidazole, benzotriazole and their derivatives, have been used extensively as ligands for the construction of complexes with intriguing structures and potential applications in fluorescent materials, nonlinear optical (NLO) and ferroelectric materials, dielectric materials and the pharmaceutical industry (Wang et al, 2010;Dou et al, 2016;Castillo et al, 2016;Brede et al, 2016). In recent years, many researchers, including our group, have focused their attention on the design and synthesis of metal-organic complexes based on 1-[(benzotriazol-1-yl)methyl]-1H-imidazole (bmi), since it has three potential N-atom donors and can coordinate to metal ions in monodentate or bridging coordination modes in the construction of complexes (An et al, 2008;Zhang et al, 2015). Up to now, more than 20 complexes constructed from the bmi ligand have been reported, ranging from zero-dimensional complexes to two-dimensional networks with a rich structural diversity.…”

Syntheses, Structures, and Properties of Two New Isostructural Complexes Based on 1-((Benzotriazol-1-yl)methyl)-1H-1,3-Imidazole and 1,4-Benzenedicarboxylate

“…[12][13][14][31][32][33] Further study showed that the coordination modes of bmi ligands in these structures could be classified into two types. For [Zn(bmi) 2 [12,14,31,33] For [Co(bmi) 2 (NO 3 ) 2 ] n , {[Cu(bmi) 2 (CH 3 OH)(H 2 O)](ClO 4 ) 2 } n , [Cd(bmi) 2 (SCN) 2 ] n , {[Ag(bmi)]¢NO 3 } n , and other five complexes, bmi coordinate to metal ions with bidentate bridging mode. [12,13,32] All the above complexes consist of only one kind of organic ligands.…”