Synthesis, crystal structures and anticancer activities of two decavanadate compounds

Abstract

Two ammonium decavanadate(V) compounds, (H 2 tmen) 3 V 10 O 28 Á6H 2 O (1) and (H 2 en) 3 V 10 O 28 Á2H 2 O (2), where H 2 tmen and H 2 en represent the doubly protonated N,N,N 0 ,N 0 -tetramethylethylenediammonium ion and doubly protonated ethylenediammonium ion, respectively, have been synthesized and structurally characterized by elemental analyses, spectroscopic (i.r., e.s.r.) studies, and single-crystal X-ray diffraction. Both crystal structures reveal the presence of the [V 10 O 28 ] 6-cluster anions, doubly protonated diammonium cations, and lattice water molecules. Hydrogen bonds assemble these two compounds to form three-dimensional networks. The in vitro anticancer activity against A549 and P388 tumor cells lines has also been determined by the MTT-based assay, and the results suggest that both compounds can inhibit proliferation of these two kinds of tumor cells.

Counterion Affects Interaction with Interfaces: The Antidiabetic Drugs Metformin and Decavanadate

“…Indeed, drug uptake has previously been found to be sensitive to counterions. [4,9,10,79] Met is often used to assist administration of other drugs, [80][81][82][83] and is known to interact with water. [33,34] The previously reported studies with the 1:2 vanadium/metformin complex that document the insulin-enhancing properties of the coordination complex found that this system had no benefit over coadministration of V and metformin.…”

Binary Decavanadate‐Betaine Composite Materials of Potential Anticarcinogenic Activity

“…The results suggest that 1 and 3 reduce cell viability of cancer cells, but do not affect the viability of normal epithelial cells, and the specific vanado-forms play a key role in the exhibited antitumor activity. [14] …”

Crystal engineering of an adenine–decavanadate molecular device towards label-free chemical sensing and biological screening

“…Ohlin, 2014). Decavanadate and its compounds were known for their insulin mimetic behavior for years but recently several papers have been published that demonstrate a variety of biological activities including anticancer, antibacterial and antivirus characteristics (Missina et al, 2018;Samart et al, 2018;Shah et al, 2014;Li et al, 2010).…”