Synthesis, crystal structure of novel unsymmetrical heterocyclic Schiff base Ni(II)/V(IV) complexes: Investigation of DNA binding, protein binding and in vitro cytotoxic activity

Sedighipoor, Maryam; Kianfar, Ali Hossein; Mohammadnezhad, Gholamhossein; Görls, Helmar; Plass, Winfried; Momtazi‐Borojeni, Amir Abbas; Abdollahi, Elham

doi:10.1016/j.ica.2018.12.051

Cited by 26 publications

(8 citation statements)

References 77 publications

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“…[5,6] The interaction of Ni (II) complexes with DNA and proteins appears to be mainly dependent on the structure of the ligand exhibiting intercalative behavior. [7][8][9][10][11][12][13] Iminodiacetic acid (IDA), an amino dicarboxylic acid, is widely used as a chelating agent to detect and remove trace elements from the biological fluids and enzyme systems [14] and also reacts with metal ions to form metal complexes with structural diversities. [15,16] Metformin, 1,1-dimethylbiguanide (Met) has antimalarial, [17] antibacterial [18] and antitumorigenic effects.…”

Section: Introductionmentioning

confidence: 99%

“…Since the discovery of urease as the first biological system for which nickel is essential for activity dates to 1975 by Dixon et al, the research area of nickel in bioinorganic chemistry has been rapidly grown . The interaction of Ni (II) complexes with DNA and proteins appears to be mainly dependent on the structure of the ligand exhibiting intercalative behavior . Iminodiacetic acid (IDA), an amino dicarboxylic acid, is widely used as a chelating agent to detect and remove trace elements from the biological fluids and enzyme systems and also reacts with metal ions to form metal complexes with structural diversities .…”

Section: Introductionmentioning

confidence: 99%

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Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

El-Shami

Ramadan

Ibrahim

et al. 2020

Applied Organom Chemis

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In quest of antimicrobial and anticancer agents, metformin containing Ni (II) complexes, [Ni (Met)2]Cl·OH (1) and [Ni (Met)(IDA)] (2) {Met: metformin, IDA: iminodiacetic acid} were synthesized and X‐ray structure of 1 is four‐coordinate square planar geometry. Bovine serum albumin (BSA) interaction and binding studies to Met, IDA and their Ni (II) complexes were investigated and showed a strong interaction. A static quenching process was proposed at low concentrations of compounds whereas, combined quenching process was observed for 1 and 2 at higher concentrations. Kinetic stability, affinity and association constants of compounds‐BSA were studied using stopped‐flow technique and a mechanism was proposed: a fast and reversible step of BSA binding including complex formation and dissociation was proposed; for the second step, a reversible reaction was observed for 1 and 2 whereas, an irreversible reaction with Met and IDA was observed indicating that coordination with nickel ions change the interaction mechanism. Additionally, the antibacterial investigation against both Gram‐positive and Gram‐negative bacteria showed that all compounds exhibited significant activities. They also show cytotoxicity against HepG2 human liver cancer cell but the half maximal inhibitory concentration (IC50) values obtained for the cell lines were higher in comparison with cisplatin. Although Met‐BSA and IDA‐BSA are kinetically more stable than that of 1‐BSA and 2‐BSA, 1‐BSA and 2‐BSA showed better antibacterial and cytotoxic activities which is in agreement with the binding constants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

El-Shami

Ramadan

Ibrahim

et al. 2020

Applied Organom Chemis

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“…In order to study these bindings, HSA is normally replaced by bovine analogous (BSA) as a model protein because of its similarity, commercial availability, and better fluorescence properties [ 62 ]. Although other fluorophores are present, BSA fluorescence is mainly due to two tryptophan residues [ 63 , 64 ].…”

Section: Resultsmentioning

confidence: 99%

Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes

et al. 2021

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New dithiocarbamate cycloaurated complexes have been synthesized and their physicochemical and in vitro antitumor properties have been evaluated. All the performed studies highlighted good transport through the blood and biodistribution, according to the balance between the properties of hydrophilicity/lipophilicity and the binding of moderate strength to the BSA protein. Furthermore, none of the complexes exhibited reduction or decomposition reactions, presenting excellent physiological stability. The in vitro cytotoxic effect was evaluated on human colon cancer cell line Caco-2/TC7, and the complexes showed great antiproliferative activity and excellent selectivity, as much less effect was detected on normal Caco-2/TC7 cells. Most of the complexes exhibit antiproliferative activity that was better than or similar to auranofin, and at least nine times better than that of cisplatin. Its action mechanism is still under discussion since no evidence of cell cycle arrest was found, but an antioxidant role was shown for some of the selective complexes. All complexes were also tested as antimicrobial drugs, exhibiting good activity towards S. aureus and E. coli. bacteria and C. albicans and C. neoformans fungi.

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“…The circular dichroism experiment is a useful method in distinguish changes in DNA morphology in interacting DNA with compounds. 5 The CD spectrum of FS-DNA includes the peak at 282 nm and another peak at 238 nm owing to base stacking and right-handed helicity, respectively, that are quite sensitive to the binding kinds of compounds with DNA. 33 The inuence of the Yb-complex on the FS-DNA conformation as showed Fig.…”

Section: The F-f Transition Of Ytterbium Complexmentioning

confidence: 99%

“…The binding of metal complexes with DNA is the topic of interest in various study elds, for example, medicinal chemistry, cancer therapy, life science, biochemistry, etc. [3][4][5][6] The metal compounds used as antitumor factors can bind to carrier proteins in the blood. Albumins are the essential extracellular and the most abundant protein constituent of the vascular system.…”

Section: Introductionmentioning

confidence: 99%

Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

et al. 2020

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Synthesis, crystal structure of novel unsymmetrical heterocyclic Schiff base Ni(II)/V(IV) complexes: Investigation of DNA binding, protein binding and in vitro cytotoxic activity

Cited by 26 publications

References 77 publications

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

Metformin Containing Nickel (II) Complexes: Synthesis, Structural Characterization, Binding and Kinetic Interactions with BSA, Antibacterial and in‐vitro Cytotoxicity Studies

Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes

Parent and nano-encapsulated ytterbium(iii) complex toward binding with biological macromolecules, in vitro cytotoxicity, cleavage and antimicrobial activity studies

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