Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential

Acylated glucosylflavones as α-glucosidase inhibitors from Tinospora crispa leaf

“…Due to limited amount of this fraction (13 mg from 43.6 g n-BuOH-soluble fraction), active constituents in this subfraction were analyzed by the combination of HPLC-DAD-SPE-NMR (Figs. 1 and 2) and HPLC-HRESIMS hyphenations, leading to the characterization of four new compounds (6,8,9,15) together with 11 known (Fig. 3).…”

“…Other therapeutic potential of such inhibitors includes the diseases related to the cell glycoprotein process such as human immunodeficiency virus (HIV) infection, hepatitis virus infection, and metastatic cancer. 11 Recently, several potent α-glucosidase inhibitors, including derivatives of oxadiazole and thiadiazole, 12 oxindole, 13 biscoumarin, 14 and 2-methoxybenzoylhydrazone, 15 4 have been developed. This study was aimed to disclose new natural α-glucosidase inhibitors from the leaf part of T. crispa.…”

Synthesis of 3,4,5-trihydroxybenzohydrazone and evaluation of their urease inhibition potential

“…Recently reported urease inhibitors are hydroxamate complex (Cheng et al, 2014), homoserine lactone derivative (Czerwonka et al, 2014), thiophosphoric triamides (Ludden et al, 2000), oxadiazoles derivatives , thioureas (Khan et al, 2014b), ethyl 4-(3-benzothioureido) benzoates derivatives , Oxindole derivatives (Taha et al, 2015c) and thiobarbituric acid derivatives (Khan et al, 2014c). However, currently available inhibitors are not efficient and the full potential of urease inhibition is yet to be discovered (Font et al, 2008).…”

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies

“…In recent past many papers are reported for urease inhibition, having Schiff base [34,35] and their metal complexes with tin (IV), Cu, Ni, Zn and Co [36]. We design our project to synthesize novel Schiff bases to evaluate their urease inhibition as well as to study the molecular basis of inhibition.…”