Synthesis, crystal structure, DNA binding and cleavage studies of copper(II) complexes with isoxazole Schiff bases

Kumar, Manish; Tejaswi, Somapangu; Rambabu, Aveli; Kalalbandi, Veerendra Kumar A.; Shivaraj,

doi:10.1016/j.poly.2015.07.052

Cited by 60 publications

(14 citation statements)

References 60 publications

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“…Consequently, varying of heterocyclic bases with the existence of bulky N(4)-substituents at the thioamide nitrogen could improve their cell-killing activity through stronger and efficient oxidative cleavage. 12,13 Consequently the data obtained for each complex showed the quality of the results with minimum concentration (5 μM) and shorter incubation period (24 h) when compared to the results of similar observations. 12,31,32 CONCLUSIONS In this study, the coordinating ability of the nine thiosemicarbazone-based copper(II) complexes C1-C9 was derived from three sulfur-containing ligands H(L1)-H(L3) with copper and diimine co-ligands.…”

Section: In Vitro Cytotoxic Evaluation By the Mtt Assaymentioning

confidence: 61%

“…12,13 Consequently the data obtained for each complex showed the quality of the results with minimum concentration (5 μM) and shorter incubation period (24 h) when compared to the results of similar observations. 12,31,32 CONCLUSIONS In this study, the coordinating ability of the nine thiosemicarbazone-based copper(II) complexes C1-C9 was derived from three sulfur-containing ligands H(L1)-H(L3) with copper and diimine co-ligands. It was concluded that the copper(II) bis complexes C1-C3 coordinated to the central metal copper through two molecules, deprotonated thiolic sulfur and azomethine nitrogen.…”

Section: In Vitro Cytotoxic Evaluation By the Mtt Assaymentioning

confidence: 61%

“…This was due to the existence of N(4)-substituted thiosemicarbazones and diimine co-ligands. 12 On the other hand, all the other complexes were found to exhibit only moderate activity. This could be explained based on the chelation theory.…”

Section: Pharmacological Resultsmentioning

confidence: 98%

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Synthesis and efficacy of copper(II) complexes bearing N(4)-substituted thiosemicarbazide and diimine co-ligands on plasmid DNA and HeLa cell lines

Rajendran¹,

Periyasamy²,

Kamatchi

et al. 2020

JSCS

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This present work deals with the synthesizes of nine novel thiosemicarbazone copper(II) complexes {[Cu(L) 2 ]Cl C3, [Cu(L)(bpy)]Cl C4-C6, [Cu(L) (phen)]Cl C7-C9 (where, L = H(L1)-H(L3), H(L1) = (E)-N-methyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene)hydrazinecarbothioamide, H(L2) = (E)-N-ethyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene) hydrazinecarbothioamide, H(L3) = (E)-N-phenyl-2-(1-phenyl-2-((5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)ethylidene) hydrazinecarbothioamide, bpy = 2,2′-bipyridyl and phen = 1,10-phenanthroline) with improved pharmacological results. The synthesized complexes were characterized by various spectral-analytical techniques. The structure of the copper(II) complexes C1-C9 was proposed by EPR spectroscopy. It confirmed the square planar coordination around Cu(II) complexes. The antibacterial screening of the complexes revealed that complexes C7 and C8 demonstrated significant activity against Gram-positive (B. thuringiensis) and Gram-negative (E. coli) bacteria. The concentration-dependent DNA cleavage activity of supercoiled (SC) pUC18 DNA exhibited complete DNA degradation effect on complex C6 at a minimum concentration of 40 μM. In vitro cytotoxic results showed that the mixed ligand copper(II) complexes C4, C5 and C7 exhibited higher effects on human cervical cancer cell lines, HeLa, when compared to cisplatin. Hence, the results obtained from each biological screening indicated the superior biological efficacy of the mixed ligand copper(II) complexes bearing diimine moieties. It could be considered as a promising alternative to an existing anticancer drug.

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Section: In Vitro Cytotoxic Evaluation By the Mtt Assaymentioning

confidence: 61%

Section: In Vitro Cytotoxic Evaluation By the Mtt Assaymentioning

confidence: 61%

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Synthesis and efficacy of copper(II) complexes bearing N(4)-substituted thiosemicarbazide and diimine co-ligands on plasmid DNA and HeLa cell lines

Rajendran¹,

Periyasamy²,

Kamatchi

et al. 2020

JSCS

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“…This suggested that the cleavage of pBR322 DNA depends on the concentration of the complexes. The different DNA cleavage efficiency of complexes ( 1) and ( 2), but especially (2), may be due to the different binding affinity of the complexes to DNA [56,57], as it has been demonstrated by UV-vis titrations experiments. Moreover, the addition of hydrogen peroxide to the DNA + complex (1)/(2) mixture contributed to the active cleavage of the DNA molecule after 5 min and caused its degradation after 2 h. This may be attributed to the formation of hydroxyl free radicals.…”

Section: Interactions Of Compounds (1) and (2) With Dnamentioning

confidence: 90%

Antibacterial Activity of Co(III) Complexes with Diamine Chelate Ligands against a Broad Spectrum of Bacteria with a DNA Interaction Mechanism

et al. 2021

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Cobalt coordination complexes are very attractive compounds for their therapeutic uses as antiviral, antibacterial, antifungal, antiparasitic, or antitumor agents. Two Co(III) complexes with diamine chelate ligands ([CoCl2(dap)2]Cl (1) and [CoCl2(en)2]Cl (2)) (where dap = 1,3-diaminopropane, en = ethylenediamine) were synthesized and characterized by elemental analysis, an ATR technique, and a scan method and sequentially tested against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration results revealed that anaerobic and microaerophilic bacteria were found to be the most sensitive; the serial passages assay presented insignificant increases in bacterial resistance to both compounds after 20 passages. The synergy assay showed a significant reduction in the MIC values of nalidixic acid when combined with Compounds (1) or (2). The assessment of cell damage by the complexes was performed using scanning electron microscopy, transmission electron microscopy, and confocal microscopy, which indicated cell membrane permeability, deformation, and altered cell morphology. DNA interaction studies of the Co(III) complexes with plasmid pBR322 using spectrophotometric titration methods revealed that the interaction between Complex (1) or (2) and DNA suggested an electrostatic and intercalative mode of binding, respectively. Furthermore, the DNA cleavage ability of compounds by agarose gel electrophoresis showed nuclease activity for both complexes. The results suggest that the effect of the tested compounds against bacteria can be complex.

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“…This fact had been result in infinite publication in coordination chemistry. So researcher infatuated to use it as medicinal power house, as anti-cancer, antibacterial, antiviral, DNA-cleavage, antitumor, anti-oxidant, [2][3][4][5][6][7] In continuation of our earlier work [8] in this study we synthesized complexes of Ni(II), and Cu and characterized by different spectral methods, also evaluated for antioxidant and microbial activity.…”

Section: Introductionmentioning

confidence: 99%

Charactrisation of Synthesized Ni (Ii), Cu (Ii) Metal Complexes and Antioxidant, Antimicrobial Study

Annapure¹

2017

WJPPS

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Synthesis, crystal structure, DNA binding and cleavage studies of copper(II) complexes with isoxazole Schiff bases

Cited by 60 publications

References 60 publications

Synthesis and efficacy of copper(II) complexes bearing N(4)-substituted thiosemicarbazide and diimine co-ligands on plasmid DNA and HeLa cell lines

Synthesis and efficacy of copper(II) complexes bearing N(4)-substituted thiosemicarbazide and diimine co-ligands on plasmid DNA and HeLa cell lines

Antibacterial Activity of Co(III) Complexes with Diamine Chelate Ligands against a Broad Spectrum of Bacteria with a DNA Interaction Mechanism

Charactrisation of Synthesized Ni (Ii), Cu (Ii) Metal Complexes and Antioxidant, Antimicrobial Study

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