Synthesis, crystal structure, cytotoxicity and action mechanism of Zn(ii) and Mn(ii) complexes with 4-([2,2′:6′,2′′-terpyridin]-4′-yl)-N,N-diethylaniline as a ligand

Abstract

Two metallo-complexes inhibited telomerase by interacting with c-myc G4-DNA and induced cell cycle arrest at the S phase.

Synthesis, Characterization, and Cytotoxicity of the Cobalt (III) Complex with N,N‐Diethyl‐4‐(2,2′:6′,2′′‐terpyridin‐4′‐yl)aniline

“…The ligand L was prepared according to reported procedures. [ ][ ] In addition, the reaction of Co(ClO 4 ) 2 with the L ligand in methanol/CH 2 Cl 2 5:2 (v/v) at 80 °C for three days furnished the Co(III) complex 1 ( Scheme ). The structure of 1 was characterized by elemental analysis, infrared spectroscopy (IR), and single crystal X‐ray diffraction (XRD) analysis ( Figure , Figures S1 and S2 ).…”

“…was investigated using the MTT assay, thus the in vitro cytotoxic potencies of ligand L and cobalt(III) complex 1 on these cell lines were evaluated. [ ][ ] The cobalt(III) complex 1 was tested against HeLa, A549, T‐24, MGC80‐3, HepG2, SK‐OV‐3, and HL‐7702 cells by MTT assay, with (L + Co(ClO 4 ) 2 ), Co(ClO 4 ) 2 , and cisplatin as the positive control and the culture medium containing 0.1% DMSO as the negative control. The cancer cells were treated with 20 μ m cobalt(III) complex 1 , Co(ClO 4 ) 2 , and cisplatin for 48 h, respectively.…”

“…Recent studies have found that many terpyridine‐metal complexes possess good affinity and high selectivity for human telomeric G‐quadruplex DNA or other G‐quadruplex DNA (c‐myc, c‐KIT, bcl‐2, etc .) . For instance, Vilar investigated the two novel [2 + 2] metallo‐assemblies, a guanosine‐substituted terpyridine palladium(II) and platinum(II) complexes, which exhibited higher interact selectively with quadruplex DNA (human telomeric G4‐DNA and the G‐rich promoter region of c‐myc oncogene) than duplex DNA, and are able to induce dimerization of parallel G‐quadruplex structures .…”

“…The Ni(II), Pt(II), Zn(II), and Mn(II) complexes of N , N ‐diethyl‐4‐(2,2′:6′,2′′‐terpyridin‐4′‐yl)aniline have been reported to stabilize G‐quadruplex DNA efficiently, inhibit telomerase activity, and regulate c‐myc gene (Pu27 G4‐DNA) expression. [ ][ ] However, to date, the cobalt(III) complex with N , N ‐diethyl‐4‐(2,2′:6′,2′′‐terpyridin‐4′‐yl)‐aniline has not been reported. [ ][ ]…”

“…[ ][ ] However, to date, the cobalt(III) complex with N , N ‐diethyl‐4‐(2,2′:6′,2′′‐terpyridin‐4′‐yl)‐aniline has not been reported. [ ][ ]…”