Synthesis, crystal structure, biological evaluation, docking study, and DFT calculations of 1-amidoalkyl-2-naphthol derivative

Amidoalkyl Naphthols as Important Bioactive Substances and Building Blocks: A Review on the Current Catalytic Mannich-Type Synthetic Approaches

“…The 1-amidoalkyl-2-naphthols possess diverse biological properties, such as antiviral, antibacterial, antifungal, and antiparasitic qualities [18][19][20][21][22]. Furthermore, members of this family are promising antioxidants, which also show cholinesterase and α-glucosidase inhibitory activities [23][24][25].…”

“…Derivative 24 was also the most potent one in the α-glucosidase assay and exhibited a greater inhibitory effect than quercetin and acarbose, which were used as standards. In vitro and in silico studies by Boudebbous et al, aimed to estimate the biological potential of another two amidoalkyl naphthol derivatives-NDHA [24] and BHMA [25] (Figure 8). Both compounds exhibited promising antioxidant properties, and in addition, NDHA was proven to be a potent acetylcholinesterase and α-glucosidase inhibitor.…”

“…They can be easily converted to aminoalkyl naphthols, the so-called Betti bases, via hydrolysis or reduction [23,[26][27][28][29] (Scheme 1). These are of great importance because of their biological activities, such as enhancing antitumor agents' cytotoxicity [30], and hypotensive and bradycardiac In vitro and in silico studies by Boudebbous et al, aimed to estimate the biological potential of another two amidoalkyl naphthol derivatives-NDHA [24] and BHMA [25] (Figure 8). Both compounds exhibited promising antioxidant properties, and in addition, NDHA was proven to be a potent acetylcholinesterase and α-glucosidase inhibitor.…”